{"id":"W3089000281","doi":"10.1038/s41467-020-18577-4","title":"A possible universal role for mRNA secondary structure in bacterial translation revealed using a synthetic operon","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Azrieli Foundation","keywords":"Operon; Translation (biology); Messenger RNA; Computational biology; Eukaryotic translation; Protein biosynthesis; Biology; Bacterial protein; Cell biology; Genetics; Bacteria; Gene; Escherichia coli","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003406334,0.0003037989,0.0003813575,0.0003723818,0.0001677748,0.0004258079,0.0001985129,0.0002594866,0.0005395434],"category_scores_gemma":[0.0005815898,0.0001612968,0.000261276,0.0001716293,0.0004675145,0.0003216839,0.0003555384,0.0003007436,0.0002676892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001787375,"about_ca_system_score_gemma":0.0002235587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001281171,"about_ca_topic_score_gemma":0.0001550434,"domain_scores_codex":[0.9997655,0.00004161255,0.00001573431,0.00008269744,0.00005449571,0.00004001382],"domain_scores_gemma":[0.9995734,0.0001098093,0.0001265066,0.00007329672,0.00005114511,0.00006587511],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005820019,0.000003435339,0.001125436,0.00002943802,0.000003325018,0.00005117696,0.00002687306,0.00008445987,0.9969903,0.0003699334,0.000007489344,0.001249949],"study_design_scores_gemma":[0.00000634411,0.0002662005,0.01691234,0.00001226517,0.00002803186,0.0005621302,0.00004572724,0.001667875,0.9775615,0.0008295878,0.002095641,0.00001233204],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.981708,0.001285465,0.0156972,0.00006396892,0.0000201928,0.00001063252,0.00009232464,0.0001241928,0.0009979329],"genre_scores_gemma":[0.9952682,0.0002171681,0.003997583,0.00002094336,0.000009030025,0.000008742006,0.00010335,0.00002591409,0.0003490928],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005395434,"threshold_uncertainty_score":0.001804948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02314702968498355,"score_gpt":0.2745342193875333,"score_spread":0.2513871897025497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}