{"id":"W3089032315","doi":"10.3389/fvets.2020.00601","title":"Foot-and-Mouth Disease: Optimization, Reproducibility, and Scalability of High-Yield Production of Virus-Like Particles for a Next-Generation Vaccine","year":2020,"lang":"en","type":"article","venue":"Frontiers in Veterinary Science","topic":"Animal Disease Management and Epidemiology","field":"Agricultural and Biological Sciences","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"Fondo para la Investigación Científica y Tecnológica","keywords":"Immunogenicity; Biosafety; Transferability; Virology; Virus; Foot-and-mouth disease; Foot-and-mouth disease virus; Biotechnology; Biology; Computer science; Immune system; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003542374,0.0009457385,0.0006217323,0.0006020872,0.000426203,0.00112479,0.0006619731,0.0008275325,0.0005497484],"category_scores_gemma":[0.002202714,0.0003469133,0.0006449607,0.0005969216,0.0004057538,0.0005604473,0.0005875872,0.0007826795,0.0004685011],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006715425,"about_ca_system_score_gemma":0.000547922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001203509,"about_ca_topic_score_gemma":0.00139744,"domain_scores_codex":[0.9967624,0.0007584724,0.0004613978,0.0004999396,0.001268195,0.0002495476],"domain_scores_gemma":[0.9990871,0.0002660032,0.0001863509,0.0001587834,0.0002472344,0.00005453191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004213466,0.00007580528,0.0003472983,0.0000695328,0.000009367477,0.00003714557,0.00004352886,0.0006781858,0.9963212,0.00006289168,0.00003900086,0.002273821],"study_design_scores_gemma":[0.00001050496,0.00026329,0.001716628,0.000008428494,0.00002445868,0.00008890035,0.0000197869,0.00226638,0.9942544,0.00004488928,0.001287028,0.00001527186],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8853246,0.002747678,0.1069636,0.000278343,0.0001070074,0.001189223,0.0008991106,0.0004432265,0.002047089],"genre_scores_gemma":[0.8474833,0.001947093,0.1446746,0.0000937412,0.00004267383,0.0009799969,0.002505369,0.0002541869,0.00201914],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003542374,"threshold_uncertainty_score":0.0187341,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09541350507306003,"score_gpt":0.2667727577510027,"score_spread":0.1713592526779427,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}