{"id":"W3089041431","doi":"10.1136/annrheumdis-2020-217646","title":"Unique expansion of IL-21+ Tfh and Tph cells under control of ICOS identifies Sjögren's syndrome with ectopic germinal centres and MALT lymphoma","year":2020,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Salivary Gland Disorders and Functions","field":"Medicine","cited_by":183,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"Birmingham Biomedical Research Centre; Medical Research Council; Versus Arthritis; National Institute for Health and Care Research; William Harvey Research Foundation; Cancer Research UK; Wellcome Trust","keywords":"Germinal center; CXCR5; FOXP3; MALT lymphoma; Immunology; Immunophenotyping; Medicine; Proinflammatory cytokine; Cytokine; Population; Immune system; Biology; B cell; Antibody; Flow cytometry; Lymphatic system; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000916386,0.0002176621,0.000228654,0.0004995143,0.0001283629,0.0003248428,0.0000779909,0.0002368106,0.001488001],"category_scores_gemma":[0.000188629,0.0001182005,0.0001706414,0.0002764835,0.0002565254,0.00009708726,0.0001432511,0.0001842081,0.0002918282],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001300126,"about_ca_system_score_gemma":0.00008576913,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00035038,"about_ca_topic_score_gemma":0.0004779568,"domain_scores_codex":[0.9998678,0.00001640272,0.00001266359,0.00003830551,0.00002928064,0.00003553231],"domain_scores_gemma":[0.9998736,0.00002606381,0.00004563235,0.00001051704,0.00001160995,0.00003258607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000602153,0.00002616323,0.0552487,0.00005466297,0.00001501723,0.002068329,0.0001888469,0.00005256566,0.9388825,0.00004911443,0.0000725375,0.002739529],"study_design_scores_gemma":[0.00003012115,0.0005060947,0.8822086,0.00001577197,0.00005939786,0.01289832,0.0005124725,0.0005419397,0.1018079,0.0001001298,0.001311589,0.000007715587],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990113,0.0001984313,0.0002603909,0.000009134797,0.000002947833,0.000008864715,0.0002107927,0.00001432756,0.0002837419],"genre_scores_gemma":[0.9989213,0.0001112901,0.0003413257,0.00002434138,0.000008590965,0.00001321003,0.0003568093,0.000006891898,0.0002162857],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001488001,"threshold_uncertainty_score":0.004977882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01956463768581924,"score_gpt":0.2423810225324106,"score_spread":0.2228163848465914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}