{"id":"W3089043805","doi":"10.1016/s2213-2600(20)30418-5","title":"Human recombinant soluble ACE2 in severe COVID-19","year":2020,"lang":"en","type":"article","venue":"The Lancet Respiratory Medicine","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":429,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; University of Toronto; St. Michael's Hospital","funders":"Horizon 2020; Canadian Institutes of Health Research; Medizinische Universität Wien; Innovative Medicines Initiative; Universität Wien; Österreichischen Akademie der Wissenschaften; Vienna Science and Technology Fund; European Federation of Pharmaceutical Industries and Associations","keywords":"Angiotensin-converting enzyme 2; Peptidyl-Dipeptidase A; Renin–angiotensin system; Angiotensin II; Recombinant DNA; Coronavirus disease 2019 (COVID-19); Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Receptor; Coronavirus; Enzyme; Medicine; Angiotensin-converting enzyme; Virology; Pharmacology; Chemistry; Biology; Internal medicine; Biochemistry; Disease; Gene; Infectious disease (medical specialty); Blood pressure","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002021086,0.0002657401,0.0008732091,0.0001704043,0.0001999642,0.00001751764,0.0006017952,0.0001476887,0.0002838741],"category_scores_gemma":[0.001920861,0.0001620125,0.00008468045,0.0008475121,0.0004498165,0.00007696416,0.0001927962,0.0009824493,0.0002141244],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002660594,"about_ca_system_score_gemma":0.0006093945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003560475,"about_ca_topic_score_gemma":0.0002211905,"domain_scores_codex":[0.997199,0.000309014,0.0005268285,0.000506139,0.0007653104,0.0006936946],"domain_scores_gemma":[0.9984415,0.0002486946,0.0001208438,0.000833204,0.00008924818,0.0002664781],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002154744,0.0002230973,0.1698128,0.001494615,0.0001283869,0.001780363,0.006142918,0.000006766736,0.1115589,0.002097805,0.7013504,0.003249191],"study_design_scores_gemma":[0.009997953,0.001339275,0.006421962,0.0001967885,0.00004734871,0.00005006143,0.0006715364,0.0001110595,0.002731481,0.0006659368,0.9775674,0.0001991614],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.7576249,0.00503209,0.00005583551,0.2027047,0.0005294827,0.001455058,0.000004771245,0.000354079,0.03223915],"genre_scores_gemma":[0.4319348,0.00001809352,0.00001411786,0.5656753,0.002070207,0.00006584897,0.000003556622,0.00003824904,0.0001797509],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.3629707,"threshold_uncertainty_score":0.6606679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2007571253089776,"score_gpt":0.4187234059169472,"score_spread":0.2179662806079696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}