{"id":"W3089043805","doi":"10.1016/s2213-2600(20)30418-5","title":"Human recombinant soluble ACE2 in severe COVID-19","year":2020,"lang":"en","type":"article","venue":"The Lancet Respiratory Medicine","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":429,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; University of Toronto; St. Michael's Hospital","funders":"Horizon 2020; Canadian Institutes of Health Research; Medizinische Universität Wien; Innovative Medicines Initiative; Universität Wien; Österreichischen Akademie der Wissenschaften; Vienna Science and Technology Fund; European Federation of Pharmaceutical Industries and Associations","keywords":"Angiotensin-converting enzyme 2; Peptidyl-Dipeptidase A; Renin–angiotensin system; Angiotensin II; Recombinant DNA; Coronavirus disease 2019 (COVID-19); Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Receptor; Coronavirus; Enzyme; Medicine; Angiotensin-converting enzyme; Virology; Pharmacology; Chemistry; Biology; Internal medicine; Biochemistry; Disease; Gene; Infectious disease (medical specialty); Blood pressure","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009549677,0.0004798055,0.000722121,0.0001103666,0.0001311502,0.0005674647,0.0002812862,0.0008577115,0.001350055],"category_scores_gemma":[0.0008023248,0.0001386772,0.0006518069,0.0001129,0.0004127605,0.0003000612,0.0002185475,0.001587433,0.0004485596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004431923,"about_ca_system_score_gemma":0.0004865472,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005743502,"about_ca_topic_score_gemma":0.0006516032,"domain_scores_codex":[0.9997495,0.000108807,0.00001909254,0.00001896911,0.00003863644,0.00006508943],"domain_scores_gemma":[0.9997209,0.0000781547,0.00003993069,0.00002506599,0.00001460723,0.0001212989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.2093171,0.006909767,0.03987706,0.001072002,0.001234935,0.01111911,0.0002555096,0.003520111,0.3445154,0.005649791,0.04137352,0.3351557],"study_design_scores_gemma":[0.06541935,0.2629802,0.3115936,0.0006169875,0.001861847,0.0274095,0.0009245445,0.01483256,0.1919899,0.005477134,0.1166649,0.0002295038],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9458251,0.030844,0.002924506,0.008723445,0.001762343,0.0002006065,0.0007189472,0.0002495443,0.008751569],"genre_scores_gemma":[0.9916894,0.003728971,0.0005799123,0.0009893881,0.0005806774,0.00002896742,0.0007259357,0.00001097172,0.001665679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001350055,"threshold_uncertainty_score":0.005050421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2007571253089776,"score_gpt":0.4187234059169472,"score_spread":0.2179662806079696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}