{"id":"W3089095538","doi":"10.1164/rccm.202008-3176le","title":"Safety and Efficacy of Elexacaftor/Tezacaftor/Ivacaftor for 24 Weeks or Longer in People with Cystic Fibrosis and One or More <i>F508del</i> Alleles: Interim Results of an Open-Label Phase 3 Clinical Trial","year":2020,"lang":"en","type":"letter","venue":"American Journal of Respiratory and Critical Care Medicine","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":166,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"National Institute of General Medical Sciences","keywords":"Ivacaftor; Medicine; Cystic fibrosis; Interim; Open label; Interim analysis; Internal medicine; Clinical trial; Cystic fibrosis transmembrane conductance regulator","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003685136,0.0007392168,0.001838024,0.0003278711,0.0005065548,0.001051318,0.0004585279,0.001637666,0.00324874],"category_scores_gemma":[0.00235797,0.0002326325,0.002053315,0.0002268047,0.0005696369,0.00107967,0.0003555011,0.00266966,0.0007250572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004196367,"about_ca_system_score_gemma":0.0007012516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002694812,"about_ca_topic_score_gemma":0.0007668717,"domain_scores_codex":[0.998997,0.0004647887,0.00007002019,0.000127729,0.0001455366,0.000194933],"domain_scores_gemma":[0.9989548,0.0002425929,0.0003125581,0.0001115716,0.0001077911,0.000270683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8025399,0.02238066,0.009816545,0.0009159609,0.002422763,0.0002946278,0.0003484568,0.0007398964,0.03158084,0.0003036849,0.002761566,0.1258951],"study_design_scores_gemma":[0.4277081,0.5145026,0.0415733,0.0002174448,0.001765608,0.00044301,0.0001760062,0.0007852775,0.0065299,0.0004986318,0.00573429,0.00006589221],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893379,0.003423148,0.0008657302,0.000590265,0.0001665123,0.001571321,0.001440082,0.0001285549,0.002476438],"genre_scores_gemma":[0.9922781,0.0009838899,0.001607249,0.000664172,0.0002048753,0.001763307,0.00103839,0.00002478947,0.001435216],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003685136,"threshold_uncertainty_score":0.01948905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0953719621599289,"score_gpt":0.4450267334802367,"score_spread":0.3496547713203079,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}