{"id":"W3089163883","doi":"10.1002/bit.27580","title":"New soluble angiopoietin analog of Hepta‐ANG1 prevents pathological vascular leakage","year":2020,"lang":"en","type":"article","venue":"Biotechnology and Bioengineering","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; McMaster University; Vale (Canada)","funders":"National Eye Institute; National Institutes of Health","keywords":"Angiopoietin receptor; Cell biology; Vascular permeability; Chemistry; Fusion protein; Activator (genetics); Angiopoietin; In vivo; Endothelial stem cell; Vascular endothelial growth factor; Cancer research; In vitro; Biology; Biochemistry; Medicine; Receptor; Pathology; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000707686,0.0001429641,0.0001897483,0.00003931082,0.00003250686,0.000005332595,0.0001656674,0.0004145145,0.00002408165],"category_scores_gemma":[0.00002897743,0.0001280702,0.0001119614,0.0001333796,0.00008192227,0.000003048961,0.0001764832,0.00009410075,0.000002722476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003897777,"about_ca_system_score_gemma":0.00002091556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007196692,"about_ca_topic_score_gemma":0.000001880817,"domain_scores_codex":[0.9992524,0.00001243403,0.0001650694,0.0003072785,0.0000598402,0.0002029976],"domain_scores_gemma":[0.999667,0.000003732873,0.0000467917,0.0001823806,0.00001448564,0.00008564492],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002597389,0.00001665577,0.002721315,0.00003973188,0.0001086856,0.00000619411,0.00001831701,0.0001004307,0.9899217,0.0003552934,0.0009733468,0.005712394],"study_design_scores_gemma":[0.0004255284,0.0004946037,0.002643658,0.00001762585,0.00004764714,0.00001538216,0.0000420814,0.0003042971,0.9544205,0.00002490472,0.0413405,0.0002232933],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9003826,0.01357116,0.08449184,0.001151694,0.0001144543,0.000141046,0.00001155505,0.00006521784,0.00007045986],"genre_scores_gemma":[0.9933149,0.001239327,0.005041508,0.0001595184,0.0001402325,0.00000518386,0.00001863536,0.00001554944,0.00006509991],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09293237,"threshold_uncertainty_score":0.5222551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01219295019023338,"score_gpt":0.2188341266178677,"score_spread":0.2066411764276343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}