{"id":"W3089186507","doi":"10.1093/neuros/nyaa430","title":"NEWTON-2 Cisternal (Nimodipine Microparticles to Enhance Recovery While Reducing Toxicity After Subarachnoid Hemorrhage): A Phase 2, Multicenter, Randomized, Open-Label Safety Study of Intracisternal EG-1962 in Aneurysmal Subarachnoid Hemorrhage","year":2020,"lang":"en","type":"article","venue":"Neurosurgery","topic":"Intracranial Aneurysms: Treatment and Complications","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Nimodipine; Medicine; Subarachnoid hemorrhage; Anesthesia; Tolerability; Vasospasm; Internal carotid artery; Cerebral vasospasm; Cerebral infarction; Surgery; Ischemia; Adverse effect; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006504917,0.0005807367,0.001623695,0.0002954086,0.0001665957,0.0001621981,0.0005482033,0.0001234293,0.0002357935],"category_scores_gemma":[0.0006019659,0.0005434107,0.0002497355,0.0008490324,0.0001522677,0.0004529089,0.0004278528,0.0006184526,0.00008192124],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001550071,"about_ca_system_score_gemma":0.0002106883,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004150954,"about_ca_topic_score_gemma":0.00009923524,"domain_scores_codex":[0.9951859,0.0004710528,0.001854284,0.001201947,0.0005716786,0.0007151965],"domain_scores_gemma":[0.9975933,0.0003823051,0.0004728276,0.0008234114,0.0002064165,0.0005217636],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3825642,0.02113437,0.02095436,0.0007337696,0.0000573804,0.007130645,0.002539747,0.0002025621,0.5371702,0.000008550708,0.00007909584,0.02742515],"study_design_scores_gemma":[0.452682,0.01148999,0.03318474,0.000264286,0.001768017,0.002214191,0.0007948665,0.06541742,0.4298919,0.00003883189,0.0001307531,0.002122889],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905802,0.000184454,0.0007594296,0.003897257,0.0003878029,0.003752381,0.0001336328,0.0001126505,0.000192183],"genre_scores_gemma":[0.9933873,0.00000799283,0.00160762,0.003679757,0.0002941931,0.0004287886,0.00004231128,0.0000864465,0.0004655612],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1072782,"threshold_uncertainty_score":0.9997017,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03245351430950481,"score_gpt":0.3070848166056262,"score_spread":0.2746313022961214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}