{"id":"W3089186507","doi":"10.1093/neuros/nyaa430","title":"NEWTON-2 Cisternal (Nimodipine Microparticles to Enhance Recovery While Reducing Toxicity After Subarachnoid Hemorrhage): A Phase 2, Multicenter, Randomized, Open-Label Safety Study of Intracisternal EG-1962 in Aneurysmal Subarachnoid Hemorrhage","year":2020,"lang":"en","type":"article","venue":"Neurosurgery","topic":"Intracranial Aneurysms: Treatment and Complications","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Nimodipine; Medicine; Subarachnoid hemorrhage; Anesthesia; Tolerability; Vasospasm; Internal carotid artery; Cerebral vasospasm; Cerebral infarction; Surgery; Ischemia; Adverse effect; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001174604,0.000952925,0.001117646,0.0003827851,0.0002071117,0.0005327645,0.0006716103,0.0009028371,0.001660364],"category_scores_gemma":[0.0006764524,0.0003760147,0.0006871,0.0002305826,0.0005372638,0.0004534567,0.000225299,0.001325063,0.000308471],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003989707,"about_ca_system_score_gemma":0.0007756944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005080325,"about_ca_topic_score_gemma":0.001285518,"domain_scores_codex":[0.999681,0.0001457101,0.0000225548,0.00005336524,0.00004925124,0.00004817071],"domain_scores_gemma":[0.9996217,0.00006891507,0.0001308723,0.00003141503,0.00002884888,0.0001181658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7750487,0.06262762,0.003445229,0.0007107483,0.001131875,0.0002936032,0.0001690153,0.0006029235,0.09826023,0.000158644,0.0008474664,0.05670384],"study_design_scores_gemma":[0.5788316,0.3995799,0.008183184,0.00002265513,0.0005331602,0.0001766948,0.00002804529,0.0005280292,0.01108117,0.00005550914,0.0009569584,0.00002320325],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974802,0.000689788,0.0003328023,0.00008327694,0.00004826038,0.0008826078,0.0001867926,0.0000371775,0.000258997],"genre_scores_gemma":[0.9939801,0.001345411,0.001788945,0.0003136243,0.0001258746,0.001006166,0.0005156784,0.00001268922,0.0009115459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001660364,"threshold_uncertainty_score":0.006211936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03245351430950481,"score_gpt":0.3070848166056262,"score_spread":0.2746313022961214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}