{"id":"W3089189913","doi":"10.1016/j.annonc.2020.08.1615","title":"1301P Blood first assay screening trial (BFAST) in patients (pts) with 1L NSCLC: ALK+ cohort updated biomarker analyses","year":2020,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Roche (Canada)","funders":"F. Hoffmann-La Roche","keywords":"Medicine; Alectinib; Cohort; Internal medicine; Oncology; Hazard ratio; Biomarker; Gastroenterology; Confidence interval; Crizotinib; Lung cancer; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007894186,0.000462225,0.0007049183,0.0003065369,0.0001823072,0.0009081694,0.0003055904,0.0004149743,0.001860938],"category_scores_gemma":[0.001141181,0.0002198125,0.0005560791,0.0004164341,0.0001555582,0.0006341666,0.0004500617,0.001002558,0.0005706232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006272335,"about_ca_system_score_gemma":0.0007072749,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001781251,"about_ca_topic_score_gemma":0.005791564,"domain_scores_codex":[0.999773,0.00006150828,0.00001549116,0.00005934144,0.00004996307,0.00004074664],"domain_scores_gemma":[0.9995607,0.00008821898,0.0001102172,0.00003463054,0.00008030039,0.0001259737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1229687,0.001530599,0.472013,0.0009664667,0.004305758,0.0005533987,0.0001852671,0.003040865,0.02879925,0.001196063,0.04315285,0.3212877],"study_design_scores_gemma":[0.0228032,0.01805908,0.898715,0.0002575626,0.00544794,0.001843765,0.00018286,0.00418592,0.005224906,0.003316428,0.03984484,0.0001184572],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9742318,0.005170921,0.0006988634,0.001739939,0.0002494263,0.0001641505,0.0130937,0.0001187431,0.004532389],"genre_scores_gemma":[0.9673854,0.002750459,0.00141592,0.00143272,0.0002461028,0.0002440196,0.02244114,0.00004076556,0.004043412],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001860938,"threshold_uncertainty_score":0.006225467,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07109172378761051,"score_gpt":0.3481032729130858,"score_spread":0.2770115491254753,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}