{"id":"W3089224428","doi":"10.1371/journal.ppat.1008852","title":"The glucosyltransferase activity of C. difficile Toxin B is required for disease pathogenesis","year":2020,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; H2020 Marie Skłodowska-Curie Actions; NIHR Nottingham Biomedical Research Centre; National Institute for Health and Care Research; Canadian Institutes of Health Research; National Institutes of Health; Biotechnology and Biological Sciences Research Council; University of Wisconsin-Madison","keywords":"Glucosyltransferase; Pathogenesis; Clostridium difficile toxin A; Clostridium difficile toxin B; Mutant; Microbiology; Biology; In vivo; Hamster; Wild type; Toxin; Inflammation; Clostridium difficile; Virology; Immunology; Molecular biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002139655,0.0002794893,0.0005064667,0.00006063104,0.000287633,0.00003656141,0.0002681136,0.0001105581,0.0001401609],"category_scores_gemma":[0.0008343835,0.0002051341,0.00050062,0.0004340557,0.000171805,0.00005935508,0.00008648915,0.0002112233,0.00004085065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007748798,"about_ca_system_score_gemma":0.0003887122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008620608,"about_ca_topic_score_gemma":0.000004845007,"domain_scores_codex":[0.9977228,0.00009221728,0.0004282216,0.0005443334,0.0006261032,0.000586314],"domain_scores_gemma":[0.9977055,0.0004708155,0.00009757916,0.0006569609,0.0003354574,0.0007337149],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00346473,0.000641237,0.000954275,0.0005551369,0.0001738079,0.00006457098,0.0002866338,0.000003026712,0.9786121,0.00008800926,0.001626551,0.01352991],"study_design_scores_gemma":[0.001911041,0.0008077836,0.002259718,0.00008002006,0.000475042,0.000003406866,0.0001542638,0.004997279,0.9838133,0.00003257544,0.005226204,0.0002393865],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9792747,0.0008936489,0.000443807,0.01547616,0.00005940339,0.001522712,0.002060015,0.00008483719,0.0001846742],"genre_scores_gemma":[0.9976231,0.0006761717,0.0001533675,0.0005971597,0.0003655963,0.0002197893,0.00006364012,0.00006763448,0.0002335568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01834834,"threshold_uncertainty_score":0.8365126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05866245956593856,"score_gpt":0.2944259422887055,"score_spread":0.2357634827227669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}