{"id":"W3089224428","doi":"10.1371/journal.ppat.1008852","title":"The glucosyltransferase activity of C. difficile Toxin B is required for disease pathogenesis","year":2020,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; H2020 Marie Skłodowska-Curie Actions; NIHR Nottingham Biomedical Research Centre; National Institute for Health and Care Research; Canadian Institutes of Health Research; National Institutes of Health; Biotechnology and Biological Sciences Research Council; University of Wisconsin-Madison","keywords":"Glucosyltransferase; Pathogenesis; Clostridium difficile toxin A; Clostridium difficile toxin B; Mutant; Microbiology; Biology; In vivo; Hamster; Wild type; Toxin; Inflammation; Clostridium difficile; Virology; Immunology; Molecular biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007906759,0.0002749594,0.0002519485,0.0001902357,0.0002044051,0.0003829448,0.0001710433,0.0002947682,0.0007482279],"category_scores_gemma":[0.0001384522,0.0001352701,0.0002293757,0.000171418,0.0002715427,0.0001310107,0.0002880924,0.0005288256,0.0003758336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003476766,"about_ca_system_score_gemma":0.0003954417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00133221,"about_ca_topic_score_gemma":0.001138655,"domain_scores_codex":[0.9998036,0.00002347383,0.00001880167,0.0000350023,0.0000627191,0.00005646229],"domain_scores_gemma":[0.9997951,0.00001814056,0.00006348298,0.00002795033,0.00002081907,0.00007436842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004633899,0.00001042979,0.0002644798,0.000008252122,0.000001061993,0.00003391342,0.000005620341,0.00002372341,0.9992477,0.00003332984,0.0000106634,0.0003145908],"study_design_scores_gemma":[0.00003598667,0.000366962,0.05786052,0.00001687108,0.00002031539,0.001193408,0.0001178818,0.001604581,0.9352501,0.0001358791,0.003382465,0.00001492729],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974987,0.0004378796,0.00102037,0.00005453428,0.000008581423,0.000009450609,0.0002337098,0.0000520818,0.00068483],"genre_scores_gemma":[0.9975932,0.0003031355,0.000973068,0.00002513373,0.000002901043,0.00001340407,0.0004576385,0.00001449773,0.000616917],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00133221,"threshold_uncertainty_score":0.00264895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05866245956593856,"score_gpt":0.2944259422887055,"score_spread":0.2357634827227669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}