{"id":"W3089234580","doi":"10.1128/mbio.01615-20","title":"Outer Membrane Disruption Overcomes Intrinsic, Acquired, and Spontaneous Antibiotic Resistance","year":2020,"lang":"en","type":"article","venue":"mBio","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Bacterial outer membrane; Antibiotic resistance; Antibiotics; Gram-negative bacteria; Bacteria; Membrane permeability; Membrane; Biology; Microbiology; Chemistry; Biochemistry; Escherichia coli; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006771916,0.0001745332,0.0001895305,0.0000177718,0.00006668662,0.00005796088,0.0001513897,0.0001368775,0.00003610667],"category_scores_gemma":[0.00008495861,0.0001665387,0.00005054997,0.00007049049,0.0001312792,0.000007802231,0.0001195252,0.00005358878,0.00003336072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001335746,"about_ca_system_score_gemma":0.00002317503,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004488452,"about_ca_topic_score_gemma":0.00004027189,"domain_scores_codex":[0.9989755,0.00004282124,0.0001973571,0.0004417098,0.0001141891,0.000228425],"domain_scores_gemma":[0.9994858,0.00001168034,0.00007316272,0.0002777195,0.00003501962,0.0001166228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005438918,0.00003175836,0.01063664,0.0001348149,0.0000506796,0.0003148216,0.0001190893,0.000001248933,0.9842699,0.0002631969,0.002115189,0.001518827],"study_design_scores_gemma":[0.002497694,0.0007169441,0.2216369,0.0001753483,0.0001195317,0.0006618035,0.0003420016,0.00005937006,0.5820733,0.0001210921,0.1902528,0.001343154],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961325,0.0007808679,0.0002383491,0.001175541,0.0001495154,0.000159076,0.00002791487,0.00002990979,0.001306324],"genre_scores_gemma":[0.9958302,0.0004724293,0.001032945,0.0009087638,0.0003037391,9.646004e-7,0.00006826239,0.00002706934,0.001355644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4021966,"threshold_uncertainty_score":0.6791249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00955113811581667,"score_gpt":0.2294381447353961,"score_spread":0.2198870066195795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}