{"id":"W3089234580","doi":"10.1128/mbio.01615-20","title":"Outer Membrane Disruption Overcomes Intrinsic, Acquired, and Spontaneous Antibiotic Resistance","year":2020,"lang":"en","type":"article","venue":"mBio","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Bacterial outer membrane; Antibiotic resistance; Antibiotics; Gram-negative bacteria; Bacteria; Membrane permeability; Membrane; Biology; Microbiology; Chemistry; Biochemistry; Escherichia coli; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002236709,0.0003178165,0.000344376,0.0001469623,0.0001405054,0.0004943603,0.0002449684,0.0004671693,0.0005551155],"category_scores_gemma":[0.0003444999,0.0001410804,0.0002037257,0.0000927263,0.0003318321,0.0003660188,0.0006161563,0.0006862953,0.0002758758],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002490116,"about_ca_system_score_gemma":0.0001943588,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001993777,"about_ca_topic_score_gemma":0.0003711747,"domain_scores_codex":[0.999698,0.00004329428,0.00001986452,0.00004413405,0.00009681626,0.00009782783],"domain_scores_gemma":[0.9998652,0.00002069159,0.0000593111,0.00001616141,0.00001447738,0.00002417335],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002860284,0.0000211414,0.0001662253,0.00005505717,0.000005471738,0.00005004658,0.00001655723,0.00008375759,0.9974352,0.0002924445,0.00007574564,0.001769743],"study_design_scores_gemma":[0.000005620645,0.0003073258,0.002605247,0.00001728692,0.00001173023,0.0002714932,0.00005196985,0.000781892,0.9893922,0.0001492925,0.006398101,0.000007893497],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9805065,0.006571916,0.007863225,0.0005670697,0.00008278942,0.00004365035,0.0001277628,0.00023171,0.004005371],"genre_scores_gemma":[0.9930173,0.002432661,0.002669033,0.0002130942,0.0000155253,0.00003120918,0.0001291537,0.00004267493,0.001449353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005551155,"threshold_uncertainty_score":0.001857102,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00955113811581667,"score_gpt":0.2294381447353961,"score_spread":0.2198870066195795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}