{"id":"W3089242719","doi":"10.1016/j.annonc.2020.08.783","title":"711P Nivolumab + ipilimumab (N+I) vs sunitinib (S) for first-line treatment of advanced renal cell carcinoma (aRCC) in CheckMate 214: 4-year follow-up and subgroup analysis of patients (pts) without nephrectomy","year":2020,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Medicine; Internal medicine; Renal cell carcinoma; Nivolumab; Intention-to-treat analysis; Sunitinib; Nephrectomy; Post-hoc analysis; Subgroup analysis; Ipilimumab; Urology; Gastroenterology; Surgery; Adverse effect; Confidence interval; Kidney; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007041305,0.0004776901,0.001662999,0.0002872895,0.000210233,0.0008076894,0.0004529032,0.0007273586,0.001636499],"category_scores_gemma":[0.0009299519,0.000250329,0.004042635,0.0003496268,0.0002418659,0.0006235734,0.0003262025,0.001200299,0.0001833809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006409123,"about_ca_system_score_gemma":0.0006705598,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00232957,"about_ca_topic_score_gemma":0.004879989,"domain_scores_codex":[0.9996111,0.00009907314,0.00002997237,0.0001162905,0.00003293526,0.0001107089],"domain_scores_gemma":[0.9996049,0.0001322621,0.0001030702,0.00003659114,0.00001778195,0.0001054437],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.717005,0.002039,0.1902281,0.0009072209,0.02120275,0.0004064325,0.0001548738,0.002787926,0.007575189,0.0002023085,0.002049323,0.05544195],"study_design_scores_gemma":[0.06440187,0.1003624,0.7742479,0.0003087722,0.0427685,0.000942597,0.0005541948,0.008425752,0.003078981,0.0008691249,0.003897514,0.0001424115],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966845,0.002343413,0.00006818474,0.00009426074,0.00006946793,0.00003005924,0.0003702556,0.000007844675,0.0003319402],"genre_scores_gemma":[0.9982731,0.0006015145,0.00006578102,0.000104935,0.00004804057,0.00003018022,0.0004612255,0.000003343392,0.0004119229],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00232957,"threshold_uncertainty_score":0.005474627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06660639058166329,"score_gpt":0.3292410095913792,"score_spread":0.2626346190097159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}