{"id":"W3089245396","doi":"10.3389/fimmu.2020.558712","title":"Peroxynitrite/PKR Axis Modulates the NLRP3 Inflammasome of Cardiac Fibroblasts","year":2020,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Lawson Health Research Institute","funders":"National Natural Science Foundation of China; Lawson Health Research Institute","keywords":"Inflammasome; Peroxynitrite; Protein kinase R; Priming (agriculture); Secretion; Cell biology; Protein kinase A; Chemistry; Phosphorylation; Lipopolysaccharide; Biology; Immunology; Biochemistry; Receptor; Enzyme; Superoxide; Mitogen-activated protein kinase kinase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002735205,0.0004797362,0.000361151,0.0001967135,0.0002024108,0.0003788013,0.0001488684,0.0003691319,0.001634773],"category_scores_gemma":[0.000187198,0.0001521622,0.000433404,0.00009410389,0.000286172,0.0003443371,0.000233653,0.0008978594,0.0003792943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001800378,"about_ca_system_score_gemma":0.0002732492,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001972544,"about_ca_topic_score_gemma":0.0002547833,"domain_scores_codex":[0.9997202,0.00005913064,0.0000365388,0.00006157457,0.00005031349,0.00007225222],"domain_scores_gemma":[0.9998863,0.00001365939,0.00004235997,0.0000119482,0.00001478829,0.00003103026],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005417337,0.00008326473,0.0001697307,0.0001093672,0.000007083667,0.0001294956,0.00002967509,0.0000375709,0.9978782,0.00006939298,0.00006113575,0.0008832968],"study_design_scores_gemma":[0.0001768514,0.00144865,0.01233671,0.00003274165,0.00005460625,0.0007196284,0.0001520452,0.0008250226,0.9814384,0.0001542802,0.002647293,0.00001370484],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894783,0.004978631,0.002664825,0.0003152915,0.0001731305,0.00008153021,0.0003464934,0.00009654181,0.001865269],"genre_scores_gemma":[0.9935765,0.002184208,0.001467367,0.0001247256,0.00004414538,0.000113477,0.0002856084,0.00001423818,0.002189807],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001634773,"threshold_uncertainty_score":0.005468845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004909440745030222,"score_gpt":0.1920963151111085,"score_spread":0.1871868743660783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}