{"id":"W3089445602","doi":"10.1038/s41525-020-00148-7","title":"Early-onset renal cell carcinoma in PTEN harmatoma tumour syndrome","year":2020,"lang":"en","type":"article","venue":"npj Genomic Medicine","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Cowden syndrome; PTEN; Kidney cancer; Renal cell carcinoma; Cancer; Kidney; Birt–Hogg–Dubé syndrome; Kidney stones; Colorectal cancer; Oncology; Internal medicine; Thyroid cancer; Endometrial cancer; Thyroid; Pathology; Surgery; PI3K/AKT/mTOR pathway; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002278628,0.0002286629,0.0003208897,0.00006548884,0.00003878897,0.000008949661,0.0003799337,0.0001488752,0.0003503025],"category_scores_gemma":[0.00007251422,0.0002122763,0.00006425515,0.0001471361,0.0001180221,0.000003343753,0.0001304139,0.0002296794,0.0001142926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000527064,"about_ca_system_score_gemma":0.0001484009,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001306101,"about_ca_topic_score_gemma":0.0000106445,"domain_scores_codex":[0.9984661,0.00007916024,0.0003843224,0.0005039757,0.0001991287,0.0003672624],"domain_scores_gemma":[0.9992481,0.0000189741,0.0001140566,0.0003205685,0.0000416512,0.0002566442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001511034,0.00001962896,0.02006296,0.00005199975,0.00001969427,0.0002325744,0.0003996028,0.00007066193,0.9573972,0.000002218534,0.02139644,0.0001959144],"study_design_scores_gemma":[0.00784909,0.00278835,0.2157727,0.0001336727,0.0001140431,0.0005198857,0.0003353062,0.0008443556,0.7167081,0.00006612822,0.05395102,0.0009173258],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929175,0.003049072,0.000167729,0.001889914,0.0002472238,0.0002142915,0.00003165625,0.00002091985,0.001461723],"genre_scores_gemma":[0.9959586,0.00005645784,0.0001616829,0.002624064,0.0006926058,0.00002309315,0.00009716003,0.00004566859,0.0003406722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2406891,"threshold_uncertainty_score":0.8656375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01651301012742575,"score_gpt":0.2392642711099295,"score_spread":0.2227512609825038,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}