{"id":"W3089506874","doi":"10.7554/elife.55911","title":"Histone deacetylase knockouts modify transcription, CAG instability and nuclear pathology in Huntington disease mice","year":2020,"lang":"en","type":"article","venue":"eLife","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Huntington Society of Canada; National Eye Institute; National Human Genome Research Institute; Huntington's Disease Society of America","keywords":"Huntingtin; Huntington's disease; Biology; Knockout mouse; Gene knockout; Trinucleotide repeat expansion; Huntingtin Protein; Gene knockin; Genetics; Histone deacetylase 2; Cell biology; Allele; Neuroscience; Histone; Gene; Histone deacetylase; Disease; Pathology; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001743208,0.0004760787,0.0002949703,0.0004893071,0.0001839771,0.0003228472,0.0003636351,0.0004797873,0.001765575],"category_scores_gemma":[0.0001072553,0.0002865561,0.0002724844,0.0001466544,0.0004673158,0.0001864793,0.0002708252,0.0007946597,0.0003159278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004019881,"about_ca_system_score_gemma":0.0001920447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001177049,"about_ca_topic_score_gemma":0.004745715,"domain_scores_codex":[0.9998186,0.00001779908,0.00002500159,0.00005232989,0.00004158137,0.00004459277],"domain_scores_gemma":[0.9997995,0.00003011683,0.00006561416,0.00001668648,0.00001047316,0.00007751208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001855517,0.00004515571,0.0002701396,0.00001305099,0.000008361168,0.00009418279,0.00002607668,0.00004961755,0.9985451,0.0001304696,0.00002675849,0.0006056215],"study_design_scores_gemma":[0.0001009178,0.0006946914,0.01973582,0.00002139183,0.00004121217,0.0004032675,0.0001338435,0.0009792072,0.9758611,0.000205373,0.001811649,0.00001155854],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965669,0.0002597708,0.001407353,0.00009174168,0.00001902318,0.00002606904,0.0006325204,0.00008771192,0.0009088102],"genre_scores_gemma":[0.9874056,0.0004751598,0.003276239,0.000112651,0.000009157363,0.00008395583,0.0007043242,0.00009129089,0.007841588],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001765575,"threshold_uncertainty_score":0.005906463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03385646990013944,"score_gpt":0.2644052279013134,"score_spread":0.2305487580011739,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}