{"id":"W3089506874","doi":"10.7554/elife.55911","title":"Histone deacetylase knockouts modify transcription, CAG instability and nuclear pathology in Huntington disease mice","year":2020,"lang":"en","type":"article","venue":"eLife","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Huntington Society of Canada; National Eye Institute; National Human Genome Research Institute; Huntington's Disease Society of America","keywords":"Huntingtin; Huntington's disease; Biology; Knockout mouse; Gene knockout; Trinucleotide repeat expansion; Huntingtin Protein; Gene knockin; Genetics; Histone deacetylase 2; Cell biology; Allele; Neuroscience; Histone; Gene; Histone deacetylase; Disease; Pathology; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008991897,0.0001788901,0.0001993832,0.00005424586,0.0001135332,0.00003366207,0.0001814236,0.00004434953,0.00008726398],"category_scores_gemma":[0.001373938,0.000190986,0.00005348809,0.0002282258,0.0002256673,0.0001263138,0.00008213038,0.0001748168,0.00005118132],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003379717,"about_ca_system_score_gemma":0.00006962715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002275565,"about_ca_topic_score_gemma":0.00001949338,"domain_scores_codex":[0.9981216,0.0003603623,0.0002710179,0.000735074,0.0002359753,0.0002759818],"domain_scores_gemma":[0.999198,0.00007283374,0.00005878908,0.0002283043,0.00003744376,0.000404594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001787187,0.0001696366,0.005860159,0.00005613645,8.839155e-7,0.00005700223,0.001689521,0.0001746744,0.9907982,0.0003668236,0.0003420112,0.0003062576],"study_design_scores_gemma":[0.001545233,0.0001591064,0.1546779,0.00001593514,0.00003025201,0.000004958879,0.0001723808,0.003355201,0.8347884,0.0001062536,0.004746184,0.0003982385],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956216,0.0001797984,0.00005953299,0.003353875,0.0001147992,0.0003103932,0.00009437571,0.0000929973,0.0001726957],"genre_scores_gemma":[0.9914489,0.00007869699,0.0001121267,0.008225646,0.00005520656,0.00001988113,0.000003036205,0.00002811962,0.00002837337],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1560098,"threshold_uncertainty_score":0.7788184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03385646990013944,"score_gpt":0.2644052279013134,"score_spread":0.2305487580011739,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}