{"id":"W3089626965","doi":"10.1073/pnas.2007297117","title":"Metabolic precision labeling enables selective probing of O-linked <i>N</i> -acetylgalactosamine glycosylation","year":2020,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Cancer Institute; Stichting voor de Technische Wetenschappen; Engineering and Physical Sciences Research Council; Canadian Institutes of Health Research; National Institutes of Health; Directorate for Biological Sciences; Biotechnology and Biological Sciences Research Council; Chemistry, Engineering and Medicine for Human Health, Stanford University; Research Councils UK; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust; Francis Crick Institute; Cancer Research UK; Government of Canada; GlaxoSmithKline; Medical Research Council; Howard Hughes Medical Institute","keywords":"Glycosylation; Glycosyltransferase; Uridine diphosphate; Biochemistry; Glycoprotein; Mutant; Chemistry; Transfection; Enzyme; Biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001735945,0.000422341,0.0002283586,0.0001518153,0.0001740292,0.0004894597,0.0003484029,0.0004752169,0.0008836524],"category_scores_gemma":[0.0001924164,0.0002166149,0.0002265676,0.0002069765,0.0004487404,0.0003614736,0.0005401325,0.0007724616,0.0003977302],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004191172,"about_ca_system_score_gemma":0.0002298871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005179195,"about_ca_topic_score_gemma":0.001117782,"domain_scores_codex":[0.9998591,0.00001958225,0.000005240999,0.00004790481,0.00004062853,0.00002750693],"domain_scores_gemma":[0.9998989,0.0000194116,0.00003263164,0.00002107832,0.00001172322,0.0000162037],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000153529,0.00000315671,0.00005352385,0.00001140533,0.000001337969,0.000008891857,0.000004303041,0.0000601346,0.9986651,0.000306327,0.0000359567,0.0008344894],"study_design_scores_gemma":[0.00000303934,0.00002613391,0.0003375431,0.000001665534,0.000002429344,0.00006649512,0.000006223084,0.000746139,0.9967036,0.0001194199,0.001983702,0.000003624569],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8379555,0.001259825,0.1481295,0.0004578519,0.00009387,0.00008685762,0.0008985351,0.0009204829,0.01019745],"genre_scores_gemma":[0.9303044,0.001365997,0.06178513,0.0002075723,0.0000185651,0.00009733191,0.0007229986,0.0002015178,0.005296469],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008836524,"threshold_uncertainty_score":0.00304085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04285597003042325,"score_gpt":0.3095504698253451,"score_spread":0.2666944997949219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}