{"id":"W3089626965","doi":"10.1073/pnas.2007297117","title":"Metabolic precision labeling enables selective probing of O-linked <i>N</i> -acetylgalactosamine glycosylation","year":2020,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Cancer Institute; Stichting voor de Technische Wetenschappen; Engineering and Physical Sciences Research Council; Canadian Institutes of Health Research; National Institutes of Health; Directorate for Biological Sciences; Biotechnology and Biological Sciences Research Council; Chemistry, Engineering and Medicine for Human Health, Stanford University; Research Councils UK; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust; Francis Crick Institute; Cancer Research UK; Government of Canada; GlaxoSmithKline; Medical Research Council; Howard Hughes Medical Institute","keywords":"Glycosylation; Glycosyltransferase; Uridine diphosphate; Biochemistry; Glycoprotein; Mutant; Chemistry; Transfection; Enzyme; Biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000817879,0.00008414186,0.0001485146,0.00008521687,0.000106917,0.00001331332,0.0004525824,0.00009342605,0.000008244413],"category_scores_gemma":[0.001370566,0.0000600008,0.00007325951,0.0007758365,0.0002846139,0.00003666049,0.0001703215,0.0001145345,6.013854e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000777994,"about_ca_system_score_gemma":0.00006300282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005444234,"about_ca_topic_score_gemma":1.197841e-7,"domain_scores_codex":[0.9984626,0.00001415539,0.0003243104,0.0002460044,0.0008250322,0.0001278741],"domain_scores_gemma":[0.9989412,0.00003475081,0.0003818804,0.00000951219,0.0005928318,0.00003979296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007556895,0.00002519845,0.00229586,0.00005558487,0.00001706646,1.153254e-9,0.000133587,0.0004277387,0.9939944,0.002156278,0.0001481908,0.0006705748],"study_design_scores_gemma":[0.0002631442,0.0001293298,0.008061871,0.0000388094,0.000007561604,0.000001334192,0.00007093209,0.002232663,0.9870246,0.001255253,0.0008539533,0.00006051986],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956042,0.0004056573,0.00003552687,0.001520435,0.000007277491,0.0003188147,0.00001402134,0.000005093876,0.002089003],"genre_scores_gemma":[0.9973019,0.00009740653,0.00230869,0.0001400795,0.00008094651,0.000009810949,0.00000116154,0.000005068667,0.00005494833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006969722,"threshold_uncertainty_score":0.2446762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04285597003042325,"score_gpt":0.3095504698253451,"score_spread":0.2666944997949219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}