{"id":"W3089652488","doi":"10.1371/journal.pone.0237138","title":"Mitochondrial bioenergetic dysfunction in the D2.mdx model of Duchenne muscular dystrophy is associated with microtubule disorganization in skeletal muscle","year":2020,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; James H. Cummings Foundation","keywords":"Sarcolemma; Duchenne muscular dystrophy; Dystrophin; Biology; Skeletal muscle; Cell biology; Microtubule; Mitochondrion; Muscular dystrophy; Tubulin; Myocyte; Endocrinology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001814402,0.000655791,0.0004783837,0.001172091,0.0004838883,0.0003521036,0.0003129006,0.0008348412,0.002988727],"category_scores_gemma":[0.0001232141,0.0003381678,0.0003193844,0.0003507696,0.000519371,0.0003071425,0.0003722059,0.0009269626,0.0003391231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000765181,"about_ca_system_score_gemma":0.0003086675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002199175,"about_ca_topic_score_gemma":0.004521644,"domain_scores_codex":[0.9997478,0.00003798539,0.00003714476,0.00008122753,0.00005334052,0.00004242768],"domain_scores_gemma":[0.999746,0.00002371893,0.00008836114,0.00001628517,0.00001529868,0.000110425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008969551,0.000269599,0.001289853,0.0001025064,0.00001615486,0.0009620864,0.00009478808,0.0001648599,0.9943205,0.0002700789,0.0002082626,0.001404312],"study_design_scores_gemma":[0.0003248685,0.003709435,0.07274672,0.0001171062,0.0001354408,0.005633504,0.0005516108,0.003417373,0.9047983,0.0003611979,0.008150402,0.00005403899],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949074,0.0006309368,0.001271863,0.0002463406,0.00004167722,0.00007876341,0.001036687,0.00009365971,0.001692585],"genre_scores_gemma":[0.985999,0.0006398361,0.002132926,0.0001237769,0.00001135832,0.0002414791,0.0008810727,0.00003447536,0.009936042],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002988727,"threshold_uncertainty_score":0.009998262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01581128225038382,"score_gpt":0.1855841622973453,"score_spread":0.1697728800469615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}