{"id":"W3089698117","doi":"10.1186/s40168-020-00914-w","title":"Faecal microbiota transplant from aged donor mice affects spatial learning and memory via modulating hippocampal synaptic plasticity- and neurotransmission-related proteins in young recipients","year":2020,"lang":"en","type":"article","venue":"Microbiome","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":272,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Directorate for Biological Sciences; Ente Cassa di Risparmio di Firenze; Biotechnology and Biological Sciences Research Council; Università degli Studi di Firenze; Deakin University; Quadram Institute Bioscience; Trent University; Fondazione Cassa di Risparmio di Firenze; University of East Anglia; Università degli Studi di Siena; Nottingham Trent University","keywords":"Hippocampus; Biology; Lachnospiraceae; Gut flora; Hippocampal formation; Synaptic plasticity; Neurotransmission; Transplantation; Cognitive decline; Microglia; Neuroscience; Immunology; Internal medicine; Inflammation; Medicine; Disease; Dementia; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001355406,0.0003368469,0.0003698018,0.0000899986,0.0001947059,0.00005364077,0.0001419535,0.0003352141,0.00002991133],"category_scores_gemma":[0.00004264111,0.0003428666,0.00006456132,0.0001590117,0.0001284663,0.00001118219,0.0001160655,0.0004802021,0.000008928781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002685397,"about_ca_system_score_gemma":0.00005430231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000734781,"about_ca_topic_score_gemma":0.0004758084,"domain_scores_codex":[0.9980204,0.0002380207,0.0003857069,0.0008079491,0.00007218037,0.0004758],"domain_scores_gemma":[0.9994604,0.00004057875,0.0001226843,0.0001104777,0.0000220282,0.0002438091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003511136,0.00005898475,0.01134602,0.0001467237,0.00005905963,0.00003606814,0.001240995,0.00006023096,0.985248,2.90142e-7,0.00002606749,0.001426425],"study_design_scores_gemma":[0.008726037,0.001469141,0.272197,0.0006748574,0.0001597248,0.0004003163,0.0001887622,0.005593379,0.7087799,0.00001292082,0.0004814422,0.001316553],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958179,0.0005693623,0.002370695,0.0003006942,0.0001267916,0.0006481193,0.0001145198,0.00003436111,0.00001755591],"genre_scores_gemma":[0.9983032,0.0001155606,0.0008039469,0.0002091661,0.00009362966,0.00001097926,0.0003764837,0.00005097652,0.00003604882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2764682,"threshold_uncertainty_score":0.9999023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006673127462991587,"score_gpt":0.2125654025218214,"score_spread":0.2058922750588298,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}