{"id":"W3089698117","doi":"10.1186/s40168-020-00914-w","title":"Faecal microbiota transplant from aged donor mice affects spatial learning and memory via modulating hippocampal synaptic plasticity- and neurotransmission-related proteins in young recipients","year":2020,"lang":"en","type":"article","venue":"Microbiome","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":272,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Directorate for Biological Sciences; Ente Cassa di Risparmio di Firenze; Biotechnology and Biological Sciences Research Council; Università degli Studi di Firenze; Deakin University; Quadram Institute Bioscience; Trent University; Fondazione Cassa di Risparmio di Firenze; University of East Anglia; Università degli Studi di Siena; Nottingham Trent University","keywords":"Hippocampus; Biology; Lachnospiraceae; Gut flora; Hippocampal formation; Synaptic plasticity; Neurotransmission; Transplantation; Cognitive decline; Microglia; Neuroscience; Immunology; Internal medicine; Inflammation; Medicine; Disease; Dementia; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002312903,0.0006158201,0.0005321048,0.0004694587,0.0001795622,0.0003488809,0.0002557756,0.0005551362,0.002079803],"category_scores_gemma":[0.0001330776,0.0001972074,0.0003769285,0.0001420811,0.0003915861,0.000423171,0.0003127822,0.001114501,0.0005360203],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002274511,"about_ca_system_score_gemma":0.0002385888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003436512,"about_ca_topic_score_gemma":0.0006099226,"domain_scores_codex":[0.9998083,0.00001366102,0.00002349045,0.00005007015,0.00003783208,0.00006673032],"domain_scores_gemma":[0.9996526,0.00001210694,0.0001248245,0.00002596718,0.00002827331,0.0001563192],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009701627,0.0002250008,0.000745552,0.00005498747,0.00001477841,0.0001225197,0.00003102756,0.00003659659,0.9953263,0.00003802838,0.00005516427,0.002379803],"study_design_scores_gemma":[0.0001981121,0.01341747,0.05564691,0.00007044146,0.0001704044,0.001379112,0.0003496077,0.0009993276,0.92392,0.0002692649,0.003544808,0.0000345289],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969255,0.0009426321,0.0009736533,0.00009988858,0.00007173,0.00002554845,0.0004388131,0.00006944537,0.0004526965],"genre_scores_gemma":[0.9919568,0.00117938,0.001880987,0.0002171574,0.00003974418,0.00008169509,0.0007687806,0.00004213175,0.003833378],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002079803,"threshold_uncertainty_score":0.00695765,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006673127462991587,"score_gpt":0.2125654025218214,"score_spread":0.2058922750588298,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}