{"id":"W3089820751","doi":"10.1186/s13148-020-00931-4","title":"TWIST1 DNA methylation is a cell marker of airway and parenchymal lung fibroblasts that are differentially methylated in asthma","year":2020,"lang":"en","type":"article","venue":"Clinical Epigenetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph’s Healthcare Hamilton; University of British Columbia; McMaster University; BC Children's Hospital","funders":"NIHR Nottingham Biomedical Research Centre; Canadian Institutes of Health Research; Rosetrees Trust; Lloyd's Tercentenary Research Foundation; Asthma and Lung UK; European Respiratory Society; Canadian Lung Association; Canadian Institute for Advanced Research; Biotechnology and Biological Sciences Research Council; Canadian Thoracic Society; Medical Research Council; Henry Smith Charity; British Columbia Lung Association; National Institute for Health and Care Research; Teva Pharmaceutical Industries","keywords":"DNA methylation; Biology; Methylation; Epigenetics; Parenchyma; Epigenomics; Gene expression; Lung; Pathology; Immunology; Cancer research; Gene; Medicine; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005398365,0.0002660717,0.0004893118,0.00005966553,0.00004069087,0.00002747477,0.0002113838,0.0004751772,0.00006018542],"category_scores_gemma":[0.0004525968,0.0002644567,0.0001914258,0.000191295,0.0001652813,0.000006025828,0.0002430263,0.0002392084,0.000004627515],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009166281,"about_ca_system_score_gemma":0.00007811904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001239768,"about_ca_topic_score_gemma":0.00004055627,"domain_scores_codex":[0.9974839,0.000371485,0.0009345738,0.0006701366,0.0002459617,0.0002939345],"domain_scores_gemma":[0.9986135,0.0001676989,0.0004564803,0.0003665775,0.0001422181,0.0002535503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003710699,0.0002764068,0.5131041,0.0002244967,0.0001018983,0.000006039064,0.0003283043,0.0005457125,0.4698679,0.00001323101,0.0002778127,0.01488307],"study_design_scores_gemma":[0.00139169,0.0007821607,0.4413199,0.00004318501,0.00005247659,3.265165e-7,0.00005958572,0.005210154,0.5482287,0.0002494992,0.002331495,0.0003308116],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838563,0.004850484,0.01011203,0.0003818637,0.0001511437,0.0003060007,0.0000549918,0.00001082439,0.0002763425],"genre_scores_gemma":[0.993763,0.003147542,0.002401229,0.0002918211,0.0001740133,0.000008543985,0.00008496842,0.00003942135,0.00008944143],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07836084,"threshold_uncertainty_score":0.9999807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03505330854802528,"score_gpt":0.3081378256852213,"score_spread":0.273084517137196,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}