{"id":"W3089820751","doi":"10.1186/s13148-020-00931-4","title":"TWIST1 DNA methylation is a cell marker of airway and parenchymal lung fibroblasts that are differentially methylated in asthma","year":2020,"lang":"en","type":"article","venue":"Clinical Epigenetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph’s Healthcare Hamilton; University of British Columbia; McMaster University; BC Children's Hospital","funders":"NIHR Nottingham Biomedical Research Centre; Canadian Institutes of Health Research; Rosetrees Trust; Lloyd's Tercentenary Research Foundation; Asthma and Lung UK; European Respiratory Society; Canadian Lung Association; Canadian Institute for Advanced Research; Biotechnology and Biological Sciences Research Council; Canadian Thoracic Society; Medical Research Council; Henry Smith Charity; British Columbia Lung Association; National Institute for Health and Care Research; Teva Pharmaceutical Industries","keywords":"DNA methylation; Biology; Methylation; Epigenetics; Parenchyma; Epigenomics; Gene expression; Lung; Pathology; Immunology; Cancer research; Gene; Medicine; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003128791,0.0001745515,0.0002689194,0.000466942,0.0002096401,0.0002030448,0.0001452268,0.0002706105,0.001863423],"category_scores_gemma":[0.0006028831,0.0001275779,0.0001682031,0.0003419955,0.0002062743,0.00009269368,0.0001908305,0.0002537421,0.0002133384],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001412218,"about_ca_system_score_gemma":0.0001070572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001058182,"about_ca_topic_score_gemma":0.001833936,"domain_scores_codex":[0.9997916,0.00004854505,0.00001989296,0.00005668362,0.00004947453,0.00003380759],"domain_scores_gemma":[0.9996756,0.00008914425,0.0001306781,0.0000190743,0.00004180586,0.00004363736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001484223,0.00002955223,0.5160927,0.0001727179,0.0001249549,0.000472751,0.0003144147,0.0001902983,0.4667448,0.00007482782,0.0002107332,0.01408809],"study_design_scores_gemma":[0.00001236997,0.0002035169,0.9704461,0.00001697705,0.00006941288,0.001739278,0.0001742106,0.0003604121,0.0263177,0.0001261541,0.0005267068,0.000007110568],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971139,0.001013327,0.0008691413,0.00004117576,0.000006285992,0.00001243982,0.0004311043,0.00001379257,0.0004987227],"genre_scores_gemma":[0.9987649,0.000175293,0.000577947,0.00001620845,0.000005083133,0.00001207933,0.0002310877,0.000003015272,0.0002144072],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001863423,"threshold_uncertainty_score":0.006233752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03505330854802528,"score_gpt":0.3081378256852213,"score_spread":0.273084517137196,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}