{"id":"W3089910952","doi":"10.3390/cells9102240","title":"Urine-Derived Epithelial Cell Lines: A New Tool to Model Fragile X Syndrome (FXS)","year":2020,"lang":"en","type":"article","venue":"Cells","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Azrieli Foundation","keywords":"Fragile X syndrome; FMR1; Fragile x; Urine; Cell culture; Autism; Cell; Cytoplasm; Biology; Messenger RNA; Intellectual disability; Cell biology; Medicine; Pathology; Genetics; Gene; Endocrinology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00002545821,0.0001895151,0.0001456259,0.00002116764,0.00004518149,0.00002643865,0.0002590954,0.00009649665,0.00007879982],"category_scores_gemma":[0.00001727041,0.000196283,0.00008465016,0.00009150248,0.00001805252,0.000002088158,0.0002227298,0.00007203816,0.0003387282],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000540565,"about_ca_system_score_gemma":0.0001230975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007142815,"about_ca_topic_score_gemma":0.000003023428,"domain_scores_codex":[0.9989692,0.00001322602,0.0001887493,0.0004457111,0.0001182575,0.0002648669],"domain_scores_gemma":[0.999427,0.000003056659,0.00003672021,0.0002306706,0.00002988118,0.0002727371],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004238678,0.00003799838,0.00001640402,0.00001895288,0.00001029971,0.000006706824,0.0001624921,0.009139198,0.9772217,0.000002355018,0.0128892,0.0004522773],"study_design_scores_gemma":[0.0005930171,0.000299409,0.0002893503,0.000004596199,0.00001020305,0.000002747888,0.00003958544,0.001579613,0.9610718,0.00003143608,0.03577762,0.0003005909],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917066,0.0001327566,0.00583794,0.0007661468,0.0001316669,0.0002599023,0.00004068103,0.00002053058,0.001103826],"genre_scores_gemma":[0.9861212,0.0001359203,0.006006283,0.005026089,0.00006822663,0.00001290916,0.00004872174,0.000042826,0.002537758],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02288842,"threshold_uncertainty_score":0.8004189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01165815683222001,"score_gpt":0.2082832574397521,"score_spread":0.196625100607532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}