{"id":"W3090015922","doi":"10.1038/s41598-020-73089-x","title":"Characterization of five novel vasopressin V2 receptor mutants causing nephrogenic diabetes insipidus reveals a role of tolvaptan for M272R-V2R mutation","year":2020,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"University of Toronto","keywords":"Nephrogenic diabetes insipidus; Arginine vasopressin receptor 2; Tolvaptan; Vasopressin; Endocrinology; Internal medicine; Mutation; Antidiuretic; Aquaporin 2; Mutant; Diabetes insipidus; Chemistry; Biology; Medicine; Receptor; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006706807,0.0003914638,0.0002298654,0.0002160518,0.0001368937,0.0001719492,0.0002355875,0.0003556661,0.0006162851],"category_scores_gemma":[0.0002277964,0.0001195487,0.0003425392,0.0001256733,0.0001836462,0.00009930943,0.0001685931,0.0003275468,0.0002043693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001854369,"about_ca_system_score_gemma":0.0001389701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006882439,"about_ca_topic_score_gemma":0.0006525422,"domain_scores_codex":[0.9998844,0.0000114746,0.00002033116,0.00002518569,0.00003666394,0.00002185672],"domain_scores_gemma":[0.9998808,0.00002272467,0.00002997934,0.000008511208,0.00001203934,0.00004594284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001800972,0.00005741876,0.001852755,0.0000273138,0.00001217626,0.002837995,0.00004445241,0.00008178187,0.9934187,0.00003899338,0.00003480171,0.001413578],"study_design_scores_gemma":[0.0001106193,0.001826393,0.07087625,0.00001780168,0.0001039828,0.04224726,0.0002701658,0.002872671,0.8772565,0.0001030689,0.004268085,0.00004719921],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989209,0.0001030713,0.0004316755,0.0000412834,0.000008689934,0.00001692055,0.0002346301,0.00001308504,0.000229856],"genre_scores_gemma":[0.9970987,0.0001337393,0.001555047,0.00004795423,0.000004987095,0.00001587546,0.0006459855,0.00001914234,0.0004786858],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006882439,"threshold_uncertainty_score":0.002061665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01179846410973112,"score_gpt":0.22306535537924,"score_spread":0.2112668912695089,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}