{"id":"W3090124015","doi":"10.1101/2020.10.05.326306","title":"Depressive-like behaviors induced by somatostatin-positive GABA neuron silencing are rescued by alpha 5 GABA-A receptor potentiation","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Canadian Institutes of Health Research; National Alliance for Research on Schizophrenia and Depression; Campbell Family Mental Health Research Institute; University of Pennsylvania","keywords":"Gene silencing; Neuroscience; Allosteric modulator; Somatostatin; Anhedonia; Psychology; Antidepressant; Internal medicine; Receptor; Endocrinology; Allosteric regulation; Biology; Medicine; Hippocampus; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007358243,0.0004184615,0.0003047243,0.000225365,0.0001001567,0.0001885147,0.000214112,0.000227559,0.001418],"category_scores_gemma":[0.00005311503,0.0001338494,0.0003675126,0.0001180929,0.0002511212,0.0001202352,0.0001551134,0.0007783878,0.0004289404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001848669,"about_ca_system_score_gemma":0.0001703762,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009115158,"about_ca_topic_score_gemma":0.001626826,"domain_scores_codex":[0.9999198,0.000007602994,0.00001082059,0.00001601836,0.00001709014,0.00002871634],"domain_scores_gemma":[0.9999274,0.000005550515,0.00002765055,0.000008132076,0.00000624304,0.00002504593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009966316,0.00002423945,0.0000645422,0.00001923,0.000004855544,0.00002546934,0.000005223978,0.00002861905,0.9988527,0.00003801999,0.00003125388,0.0008061308],"study_design_scores_gemma":[0.0000435809,0.001007836,0.004098495,0.000007587755,0.00002864321,0.0001213685,0.0000317661,0.0006693515,0.9928011,0.00003768754,0.001147303,0.000005399765],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945353,0.0005946935,0.002380727,0.000118535,0.00005455952,0.00004761717,0.0007584157,0.0002105371,0.001299608],"genre_scores_gemma":[0.9940455,0.0006708076,0.001777498,0.00007128865,0.00001118617,0.00007603662,0.0005826104,0.00002663362,0.002738444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001418,"threshold_uncertainty_score":0.004743636,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01789167227141929,"score_gpt":0.2304027687339375,"score_spread":0.2125110964625182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}