{"id":"W3090148470","doi":"10.1016/j.jcmgh.2020.09.013","title":"Crohn’s Disease Pathobiont Adherent-Invasive E coli Disrupts Epithelial Mitochondrial Networks With Implications for Gut Permeability","year":2020,"lang":"en","type":"article","venue":"Cellular and Molecular Gastroenterology and Hepatology","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; McGill University; University of Calgary","funders":"Canadian Institutes of Health Research; International Microbiome Centre, University of Calgary; University of Calgary","keywords":"Biology; Mitochondrion; Mitochondrial fission; Mitochondrial apoptosis-induced channel; Escherichia coli; Molecular biology; Cell biology; Biochemistry; Inner mitochondrial membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008326834,0.0002719427,0.0003535266,0.00002859724,0.0002387392,0.00002422918,0.0001581229,0.0001777735,0.000005336998],"category_scores_gemma":[0.0001849091,0.0002403464,0.000112831,0.00004545834,0.0006381567,0.000006185314,0.0002609663,0.0001705161,7.114671e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001013347,"about_ca_system_score_gemma":0.00009845111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008111914,"about_ca_topic_score_gemma":0.000137218,"domain_scores_codex":[0.998183,0.0002231264,0.0002328615,0.0007653066,0.00006394474,0.0005317879],"domain_scores_gemma":[0.9990294,0.00003924243,0.00008841058,0.0002870436,0.0001420862,0.0004138036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.007893096,0.0001875209,0.2887381,0.0001683419,0.000370766,0.0001610667,0.0001338513,0.00006997737,0.7003178,0.0006836745,0.0008705161,0.0004052674],"study_design_scores_gemma":[0.02496378,0.02032682,0.8824536,0.00008275486,0.001552577,0.0003358715,0.0005293086,0.007735895,0.03295474,0.001415808,0.02569424,0.001954617],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9079211,0.00126495,0.08531108,0.004391924,0.00007917052,0.0008545648,0.0001448462,0.00001700148,0.00001533524],"genre_scores_gemma":[0.9947141,0.0005476747,0.001146353,0.002614933,0.0001960996,0.0004574078,0.000277121,0.00002997993,0.00001629186],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.667363,"threshold_uncertainty_score":0.9801041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01216414339244516,"score_gpt":0.2465028525239459,"score_spread":0.2343387091315007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}