{"id":"W3090148470","doi":"10.1016/j.jcmgh.2020.09.013","title":"Crohn’s Disease Pathobiont Adherent-Invasive E coli Disrupts Epithelial Mitochondrial Networks With Implications for Gut Permeability","year":2020,"lang":"en","type":"article","venue":"Cellular and Molecular Gastroenterology and Hepatology","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; McGill University; University of Calgary","funders":"Canadian Institutes of Health Research; International Microbiome Centre, University of Calgary; University of Calgary","keywords":"Biology; Mitochondrion; Mitochondrial fission; Mitochondrial apoptosis-induced channel; Escherichia coli; Molecular biology; Cell biology; Biochemistry; Inner mitochondrial membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001180132,0.0002312991,0.0001822461,0.000177998,0.0001667502,0.0003410535,0.00007993426,0.0003794848,0.001041373],"category_scores_gemma":[0.0001198329,0.0001042215,0.0001764676,0.0001179214,0.0002082938,0.0001628449,0.0001933737,0.0005414478,0.0001782174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00025139,"about_ca_system_score_gemma":0.0001008667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002681135,"about_ca_topic_score_gemma":0.0004357467,"domain_scores_codex":[0.9998289,0.00003463848,0.00001655798,0.00003028422,0.00004065932,0.00004888965],"domain_scores_gemma":[0.9998955,0.00001398477,0.00003496719,0.00001086057,0.00001649342,0.00002833171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002007212,0.0000496789,0.001490019,0.0000690992,0.00000852262,0.000245327,0.00002291948,0.00004953901,0.9961034,0.00006566432,0.0000578205,0.001637343],"study_design_scores_gemma":[0.00008629641,0.001762974,0.1167173,0.00005453526,0.00005718457,0.004596391,0.0003294672,0.002038721,0.8666921,0.000271121,0.007380475,0.00001348172],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964641,0.001622488,0.0008654378,0.0001672048,0.0000177328,0.00001623817,0.0001182288,0.00002198976,0.000706657],"genre_scores_gemma":[0.9970591,0.0008359377,0.001039693,0.0001029897,0.000008535835,0.00001860639,0.0002423192,0.00000342072,0.0006893564],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001041373,"threshold_uncertainty_score":0.003483772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01216414339244516,"score_gpt":0.2465028525239459,"score_spread":0.2343387091315007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}