{"id":"W3090185976","doi":"10.1021/acsomega.0c02467","title":"Combination of Selective PARP3 and PARP16 Inhibitory Analogues of Latonduine A Corrects F508del-CFTR Trafficking","year":2020,"lang":"en","type":"article","venue":"ACS Omega","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Cystic Fibrosis Canada","keywords":"Chemistry; In vitro; IC50; Potency; Cystic fibrosis transmembrane conductance regulator; Stereochemistry; Regulator; Mechanism of action; Pharmacology; Biochemistry; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001431762,0.000103154,0.000370246,0.0001160694,0.00002827869,0.000006095225,0.00005846696,0.00005350305,0.00000457702],"category_scores_gemma":[0.0009068493,0.00009256671,0.00003886122,0.000450917,0.0001724951,0.0001071239,0.00004984277,0.0001671252,0.000002727375],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003255997,"about_ca_system_score_gemma":0.0000933649,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002943332,"about_ca_topic_score_gemma":0.00001445435,"domain_scores_codex":[0.9989632,0.00005048208,0.0002681874,0.0002027255,0.0003454503,0.0001700063],"domain_scores_gemma":[0.9991274,0.0002729391,0.000131612,0.0001096912,0.0002267126,0.0001316786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001746996,0.0005635723,0.08023716,0.001613145,0.0002820745,0.00004539643,0.006476774,0.0001369201,0.8706995,0.000596001,0.006375241,0.03122719],"study_design_scores_gemma":[0.005579031,0.004996798,0.1753218,0.0007007473,0.0001525106,0.00003570859,0.001372766,0.003540005,0.8039783,0.0002980043,0.003757776,0.0002665842],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968703,0.001407385,0.0001324947,0.000770224,0.00003470554,0.0003121069,0.00001564311,0.00003429458,0.0004228171],"genre_scores_gemma":[0.9990494,0.0001213769,0.0005716375,0.0001190254,0.00005050173,0.00000978874,0.00003016086,0.00001429121,0.00003377345],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09508459,"threshold_uncertainty_score":0.3774761,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02330993567292353,"score_gpt":0.2872882226415862,"score_spread":0.2639782869686627,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}