{"id":"W3090185976","doi":"10.1021/acsomega.0c02467","title":"Combination of Selective PARP3 and PARP16 Inhibitory Analogues of Latonduine A Corrects F508del-CFTR Trafficking","year":2020,"lang":"en","type":"article","venue":"ACS Omega","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Cystic Fibrosis Canada","keywords":"Chemistry; In vitro; IC50; Potency; Cystic fibrosis transmembrane conductance regulator; Stereochemistry; Regulator; Mechanism of action; Pharmacology; Biochemistry; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002228558,0.0003237083,0.0004970453,0.0002257482,0.0001690287,0.0004121373,0.0003595295,0.0005016594,0.005456376],"category_scores_gemma":[0.0002386454,0.00012792,0.0003840588,0.0001944806,0.000237245,0.0003989379,0.0002450134,0.00115107,0.0009126007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000325767,"about_ca_system_score_gemma":0.0003531112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006676548,"about_ca_topic_score_gemma":0.001516147,"domain_scores_codex":[0.9998612,0.00002693634,0.00001484111,0.0000322458,0.00003040089,0.00003422604],"domain_scores_gemma":[0.9999193,0.00001257842,0.00001862583,0.00001132676,0.000008282867,0.00002992497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008798657,0.001122918,0.0009493341,0.0005206664,0.0002315983,0.0006028114,0.00007994186,0.001454678,0.8886198,0.001060017,0.006052218,0.09050733],"study_design_scores_gemma":[0.003344995,0.01243968,0.004360164,0.00006360054,0.0002154778,0.002471972,0.0001246224,0.002765281,0.9174232,0.0005151366,0.05621823,0.00005767505],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9552574,0.0193916,0.00589605,0.00110679,0.0006443788,0.0003612711,0.002163084,0.0008677099,0.01431175],"genre_scores_gemma":[0.9863216,0.004454291,0.002359341,0.0002707865,0.00004253986,0.00009059656,0.001417312,0.00005024318,0.004993322],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005456376,"threshold_uncertainty_score":0.01825345,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02330993567292353,"score_gpt":0.2872882226415862,"score_spread":0.2639782869686627,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}