{"id":"W3090236853","doi":"10.1055/s-0040-1716751","title":"Serpins, New Therapeutic Targets for Hemophilia","year":2020,"lang":"en","type":"review","venue":"Thrombosis and Haemostasis","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Blood Foundation; Société Française d'Hématologie; Ottawa Hospital Research Institute; Université de Paris; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; CSL Behring","keywords":"Serpin; Antithrombin; Hemostasis; Coagulation; Serine protease; Factor IX; Medicine; Protease; Anticoagulant; Coagulopathy; Immunology; Protease inhibitor (pharmacology); Thrombin; Protein C; Pharmacology; Chemistry; Heparin; Internal medicine; Biochemistry; Enzyme; Virus; Platelet","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003759821,0.0006542057,0.0008564795,0.002138899,0.0002026818,0.0006861904,0.0005556719,0.0008341229,0.004147083],"category_scores_gemma":[0.0005441865,0.0001572741,0.0004487729,0.001302756,0.0002727024,0.000905252,0.0004441295,0.001682045,0.001681877],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003874573,"about_ca_system_score_gemma":0.000616789,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006084768,"about_ca_topic_score_gemma":0.001239039,"domain_scores_codex":[0.9998653,0.00002264893,0.00001907555,0.00002302823,0.00005579563,0.00001414567],"domain_scores_gemma":[0.9998274,0.00007635589,0.00002731929,0.000004934768,0.00004429304,0.0000196486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000984818,0.00008184783,0.0001342056,0.01790214,0.0001090538,0.0002474942,0.00005715905,0.0002703771,0.002601878,0.003126842,0.03816988,0.9372007],"study_design_scores_gemma":[0.00003117307,0.0001118041,0.0005622589,0.002818671,0.0001534714,0.001339886,0.00003557999,0.00007303528,0.0005264381,0.001347181,0.9929863,0.00001416943],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001157781,0.9988291,0.00008625919,0.0001799226,0.0001645161,0.000004462378,0.00001962301,0.000008177755,0.0005921995],"genre_scores_gemma":[0.0007504824,0.9981358,0.000144021,0.0002248593,0.0001613656,0.000006127636,0.00004972214,0.000001794445,0.0005258135],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004147083,"threshold_uncertainty_score":0.0138734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2363948705954034,"score_gpt":0.4377723480012302,"score_spread":0.2013774774058268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}