{"id":"W3090691936","doi":"10.1124/dmd.120.000139","title":"Cell Type–Specific Roles of CD38 in the Interactions of Isoniazid with NAD+ in the Liver","year":2020,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Calcium signaling and nucleotide metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Center for Complementary and Integrative Health; National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"NAD+ kinase; CD38; Metabolite; Biochemistry; Chemistry; Glycerol-3-phosphate dehydrogenase; Biology; Molecular biology; Enzyme; Cell biology; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001904838,0.00007928197,0.000125788,0.00003498383,0.00002763927,0.00001334317,0.0001197508,0.00002922142,0.000007437454],"category_scores_gemma":[0.00001071877,0.00004666597,0.00003789968,0.0001804305,0.00006219602,0.000007855732,0.00002117128,0.00009013698,0.000001195637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001112613,"about_ca_system_score_gemma":0.0000126246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007663479,"about_ca_topic_score_gemma":0.00007622768,"domain_scores_codex":[0.9993803,0.0001442104,0.0001550411,0.0001383233,0.000100964,0.00008116753],"domain_scores_gemma":[0.9997147,0.0000271761,0.00006744418,0.0001359185,0.00003589053,0.00001888049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007472567,0.0003198452,0.001660833,0.00007250581,0.00002131788,0.00000699271,0.01308148,0.0002097633,0.9763994,0.002236226,0.001724066,0.003520277],"study_design_scores_gemma":[0.00346441,0.0003891569,0.2524327,0.0001047166,0.0002432558,0.00003947155,0.01475682,0.0005169723,0.6303583,0.0002683369,0.09695876,0.0004670782],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892272,0.009542078,0.0001550618,0.0005022243,0.00003761214,0.0001210999,0.00002047653,0.000001778534,0.0003924964],"genre_scores_gemma":[0.9983519,0.001035046,0.0000916542,0.0003535693,0.0001015148,0.000007041219,0.0000414122,0.000006102773,0.00001178505],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3460411,"threshold_uncertainty_score":0.1902983,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008939680324235158,"score_gpt":0.2170469970441697,"score_spread":0.2081073167199345,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}