{"id":"W3090736401","doi":"10.1016/j.jmoldx.2020.09.006","title":"Staining Performance of ALK and ROS1 Immunohistochemistry and Influence on Interpretation in Non–Small-Cell Lung Cancer","year":2020,"lang":"en","type":"article","venue":"Journal of Molecular Diagnostics","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Universitair Ziekenhuis Antwerpen; Vrije Universiteit Amsterdam; Clovis Oncology; Merck Sharp and Dohme; Bristol-Myers Squibb Canada; Bio-Rad Laboratories; Roche; Novartis; Meso Scale Diagnostics; Takeda Pharmaceutical Company; AbbVie; Merck; Bristol-Myers Squibb; AstraZeneca; Bayer; Pfizer; Boehringer Ingelheim","keywords":"Anaplastic lymphoma kinase; Immunohistochemistry; ROS1; Staining; Lung cancer; Pathology; Medicine; Cancer; Cancer research; Biology; Internal medicine; Adenocarcinoma","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01652267,0.0004173398,0.0003393641,0.001140299,0.0004907479,0.0009201944,0.0004881763,0.0005529117,0.001082677],"category_scores_gemma":[0.02915981,0.0002394687,0.0007004627,0.0007126121,0.0008039688,0.0005889188,0.0009071464,0.0003180211,0.0003274194],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007077711,"about_ca_system_score_gemma":0.0003367206,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00152305,"about_ca_topic_score_gemma":0.002374074,"domain_scores_codex":[0.9871275,0.005084384,0.001687208,0.002305887,0.003123254,0.0006716987],"domain_scores_gemma":[0.9735631,0.009281894,0.006101239,0.00223215,0.007877217,0.0009443914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003218045,0.0002045592,0.932409,0.0002168317,0.0003102352,0.0003483129,0.002188021,0.001569948,0.02021472,0.0001566579,0.0006014652,0.03856214],"study_design_scores_gemma":[0.00002520701,0.001368557,0.9751447,0.0000442563,0.0001780181,0.0004346446,0.000663885,0.002216519,0.0175304,0.0001970547,0.002153079,0.00004371005],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950886,0.0007627382,0.002530307,0.00005874988,0.00003462899,0.0000772749,0.0001561069,0.00003860322,0.001253038],"genre_scores_gemma":[0.9977185,0.0001122849,0.001397446,0.00003143171,0.00001793012,0.00003445436,0.0002777655,0.00002774191,0.0003825236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01652267,"threshold_uncertainty_score":0.0873813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004836796343790798,"score_gpt":0.2930180849642651,"score_spread":0.2881812886204743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}