{"id":"W3090736401","doi":"10.1016/j.jmoldx.2020.09.006","title":"Staining Performance of ALK and ROS1 Immunohistochemistry and Influence on Interpretation in Non–Small-Cell Lung Cancer","year":2020,"lang":"en","type":"article","venue":"Journal of Molecular Diagnostics","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Universitair Ziekenhuis Antwerpen; Vrije Universiteit Amsterdam; Clovis Oncology; Merck Sharp and Dohme; Bristol-Myers Squibb Canada; Bio-Rad Laboratories; Roche; Novartis; Meso Scale Diagnostics; Takeda Pharmaceutical Company; AbbVie; Merck; Bristol-Myers Squibb; AstraZeneca; Bayer; Pfizer; Boehringer Ingelheim","keywords":"Anaplastic lymphoma kinase; Immunohistochemistry; ROS1; Staining; Lung cancer; Pathology; Medicine; Cancer; Cancer research; Biology; Internal medicine; Adenocarcinoma","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005115931,0.00007151976,0.0001717816,0.00004717601,0.00001503877,0.000008554851,0.00003156072,0.00003311467,0.000002767145],"category_scores_gemma":[0.000216746,0.00006226119,0.00002389195,0.00007271527,0.00002889063,0.00004940843,0.0000164512,0.000148859,1.039002e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006856796,"about_ca_system_score_gemma":0.0001309673,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001635013,"about_ca_topic_score_gemma":7.243178e-7,"domain_scores_codex":[0.9994892,0.000009391944,0.0002400326,0.00007366295,0.0001182374,0.00006949332],"domain_scores_gemma":[0.9994793,0.00007687624,0.0001860903,0.00004930715,0.0001331659,0.00007529078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007629439,0.0002387047,0.6352948,0.001547295,0.0002772829,0.000479661,0.00880498,0.01833958,0.3197354,0.00001482837,0.0001270707,0.01437747],"study_design_scores_gemma":[0.01127159,0.004274517,0.557327,0.007029903,0.001730883,0.0001465627,0.001304581,0.03188856,0.384486,0.00002716403,0.0001547084,0.0003584665],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933097,0.005530556,0.0004421845,0.000418026,0.00002518818,0.0001206832,0.000004358578,0.000001633129,0.0001476248],"genre_scores_gemma":[0.9957963,0.00290176,0.0007950914,0.000467249,0.00001864458,0.000005050384,0.000001942179,0.000008495696,0.000005479491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07796777,"threshold_uncertainty_score":0.2538938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004836796343790798,"score_gpt":0.2930180849642651,"score_spread":0.2881812886204743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}