{"id":"W3090916012","doi":"10.3389/fimmu.2020.583820","title":"Polyfunctional Fc Dependent Activity of Antibodies to Native Trimeric Envelope in HIV Elite Controllers","year":2020,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver; Centre Hospitalier de l’Université de Montréal; McGill University; Université de Montréal; McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; McGill University Health Centre; McGill University","keywords":"Antibody-dependent cell-mediated cytotoxicity; Tetherin; Antibody; Epitope; Virology; Immune system; Biology; HIV vaccine; Immunology; Cell culture; Viral envelope; Monoclonal antibody; Vaccine trial","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002117888,0.0002019667,0.0001753586,0.00027735,0.0001176143,0.0003571131,0.0002325983,0.0002459133,0.001719506],"category_scores_gemma":[0.0003099777,0.00008915214,0.0001443212,0.0001302977,0.0001406495,0.0001913751,0.000146532,0.0004329942,0.0001421843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002578326,"about_ca_system_score_gemma":0.0001009875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008959557,"about_ca_topic_score_gemma":0.0007467104,"domain_scores_codex":[0.9998715,0.00001970464,0.000007803921,0.00002229957,0.00003049505,0.00004827036],"domain_scores_gemma":[0.9998902,0.00002491749,0.00001686973,0.00001955811,0.00001560914,0.00003278774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002414576,0.0004874888,0.006925954,0.00006250344,0.00003119152,0.0001922057,0.00007312781,0.000326487,0.9649606,0.0002346913,0.0002362802,0.0240549],"study_design_scores_gemma":[0.0006119401,0.02239429,0.1599971,0.00003821814,0.0001943758,0.002939414,0.0001564264,0.007075768,0.8000901,0.0003111802,0.006170597,0.00002051171],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988111,0.0003841124,0.0001640075,0.00001172743,0.000005621047,0.0000133036,0.0000612923,0.00001143306,0.0005374591],"genre_scores_gemma":[0.9987273,0.0001312429,0.0001426148,0.00002206193,0.0000074478,0.00001281897,0.0001921601,0.000002299353,0.0007619426],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001719506,"threshold_uncertainty_score":0.005752325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01360950130690201,"score_gpt":0.2497903988208391,"score_spread":0.2361808975139371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}