{"id":"W3090930135","doi":"10.1093/nar/gkaa800","title":"Evolution of a highly functional circular DNA aptamer in serum","year":2020,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Key Research and Development Program of China; Natural Sciences and Engineering Research Council of Canada; China Postdoctoral Science Foundation","keywords":"Biology; Aptamer; DNA; Circular DNA; Genetics; Computational biology; Base sequence; Evolutionary biology; Gene; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003697443,0.0003038789,0.0002653302,0.0003025459,0.0001491663,0.0004421626,0.0003136209,0.0004914742,0.0004862714],"category_scores_gemma":[0.0005508037,0.000258367,0.0001995734,0.0002926105,0.0002737888,0.0002065495,0.0004349687,0.0004451931,0.0004626845],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004734545,"about_ca_system_score_gemma":0.0004242803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000996914,"about_ca_topic_score_gemma":0.0008209723,"domain_scores_codex":[0.9997142,0.00005618208,0.00002302833,0.00006672436,0.00009397079,0.00004587267],"domain_scores_gemma":[0.9997991,0.00003989057,0.00005070059,0.00001750814,0.00003908069,0.00005384029],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002940861,0.000009084473,0.0001166828,0.0000144604,0.000002178881,0.00002736237,0.00001753658,0.0002628803,0.997476,0.0001263745,0.00002028922,0.0018978],"study_design_scores_gemma":[0.00001037829,0.0001295996,0.0004843068,0.000004378714,0.000007514612,0.0001860542,0.00001247345,0.003172599,0.9936413,0.0000666956,0.002276958,0.000007759453],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9389648,0.001211729,0.05665717,0.0002658626,0.00005779797,0.0001660211,0.0002502733,0.0004300277,0.001996358],"genre_scores_gemma":[0.9406689,0.0007008463,0.05205767,0.0001183866,0.000008646459,0.00006224922,0.0005669016,0.0001049862,0.005711392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000996914,"threshold_uncertainty_score":0.003435194,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03691001226271377,"score_gpt":0.3177177955376731,"score_spread":0.2808077832749593,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}