{"id":"W3090930135","doi":"10.1093/nar/gkaa800","title":"Evolution of a highly functional circular DNA aptamer in serum","year":2020,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Key Research and Development Program of China; Natural Sciences and Engineering Research Council of Canada; China Postdoctoral Science Foundation","keywords":"Biology; Aptamer; DNA; Circular DNA; Genetics; Computational biology; Base sequence; Evolutionary biology; Gene; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004339515,0.00009401111,0.0001463792,0.0001287583,0.00005782452,0.00001034264,0.0001686983,0.0001612407,0.0000154307],"category_scores_gemma":[0.0002368696,0.00008707712,0.00008736703,0.0005604759,0.0002110897,0.000005152378,0.0001558685,0.0002237675,0.00001283499],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005118297,"about_ca_system_score_gemma":0.0001022837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002830927,"about_ca_topic_score_gemma":0.000012782,"domain_scores_codex":[0.9986306,0.0001469736,0.0002066308,0.0003559589,0.0003890345,0.0002707599],"domain_scores_gemma":[0.999374,0.00001358109,0.00004150437,0.0002479852,0.0002380716,0.00008484259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001192256,0.00005225912,0.008260611,0.0000224136,0.00002280958,0.000004439536,0.00002424484,0.00001787587,0.9882128,0.0001756272,0.001378802,0.001708888],"study_design_scores_gemma":[0.0004473116,0.0004801663,0.02524356,0.00002301706,0.000008487184,0.000005152426,0.0002698123,0.0009533662,0.9568389,0.0003847508,0.01518185,0.0001636155],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954724,0.0002550562,0.002151601,0.001009205,0.00001680506,0.0001316384,0.00001490518,0.00002141857,0.000927019],"genre_scores_gemma":[0.9984137,0.00007710062,0.00104677,0.0001129571,0.0001604555,0.000006813989,0.00003203793,0.00001554732,0.0001346464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03137389,"threshold_uncertainty_score":0.3550902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03691001226271377,"score_gpt":0.3177177955376731,"score_spread":0.2808077832749593,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}