{"id":"W3090984746","doi":"10.1007/s00262-020-02728-z","title":"Anti-leukemia effect associated with down-regulated CD47 and up-regulated calreticulin by stimulated macrophages in co-culture","year":2020,"lang":"en","type":"article","venue":"Cancer Immunology Immunotherapy","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Mount Sinai Hospital; National Research Council Canada","funders":"","keywords":"CD47; Calreticulin; Lipopolysaccharide; Peripheral blood mononuclear cell; THP1 cell line; Macrophage; Immune system; Myeloid leukemia; Cell culture; Phagocytosis; Cancer research; Leukemia; In vitro; Tumor necrosis factor alpha; Myeloid; Chemistry; Immunology; Biology; Cell biology; Endoplasmic reticulum; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002516698,0.0004866326,0.0006353614,0.0003113369,0.0002476164,0.0003876973,0.000286445,0.0003390087,0.001865424],"category_scores_gemma":[0.0001366259,0.0001781712,0.0004325387,0.0003215144,0.0002463098,0.0002482041,0.0003809241,0.001275938,0.0009329662],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002234328,"about_ca_system_score_gemma":0.0003260311,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005375766,"about_ca_topic_score_gemma":0.0007659752,"domain_scores_codex":[0.9995826,0.00008697419,0.00003936801,0.00006514177,0.00007243447,0.0001534951],"domain_scores_gemma":[0.9998391,0.00003753138,0.00002131044,0.00003481203,0.0000302758,0.00003696043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007314656,0.0001131944,0.0001369208,0.00003758561,0.000006066386,0.00007097476,0.00002143793,0.00003136208,0.997872,0.00006503167,0.00006263763,0.0008513268],"study_design_scores_gemma":[0.00006401533,0.0004603545,0.002586509,0.000006037056,0.00001989465,0.0001857057,0.00002981263,0.0005702214,0.9939297,0.0000335454,0.002109259,0.000004894112],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938453,0.001901175,0.001639329,0.0002083643,0.0001558368,0.00003861257,0.000351737,0.00006781753,0.001791859],"genre_scores_gemma":[0.9875759,0.001171699,0.003272668,0.0001533298,0.0000931044,0.0001076343,0.0008741096,0.00004142245,0.006710147],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001865424,"threshold_uncertainty_score":0.006240427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007789410902745578,"score_gpt":0.2504423766042135,"score_spread":0.2426529657014679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}