{"id":"W3091008894","doi":"10.34172/apb.2022.008","title":"Diazepam Loaded Solid Lipid Nanoparticles: In Vitro and in Vivo Evaluations","year":2020,"lang":"en","type":"article","venue":"Advanced Pharmaceutical Bulletin","topic":"Advancements in Transdermal Drug Delivery","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute for Medical Research Development; University of Tehran","keywords":"Solid lipid nanoparticle; Stearic acid; In vivo; Sonication; Polyvinyl alcohol; Zeta potential; Pharmacology; Chromatography; Pulmonary surfactant; Diazepam; Polysorbate; Cryoprotectant; Particle size; Chemistry; Nanocapsules; Swelling; Drug; Drug delivery; Materials science; Nanoparticle; Medicine; Nanotechnology; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000183697,0.0002762456,0.0002105682,0.0001434326,0.0000872423,0.0001173497,0.0001330131,0.0002499796,0.000412627],"category_scores_gemma":[0.000153473,0.00008369493,0.0001855407,0.00007956315,0.0001622528,0.0001681941,0.0001083951,0.0002720436,0.0001647766],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001876669,"about_ca_system_score_gemma":0.0001195518,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004425168,"about_ca_topic_score_gemma":0.0005668125,"domain_scores_codex":[0.9999202,0.00001487034,0.000006546959,0.0000153068,0.00003036426,0.00001257645],"domain_scores_gemma":[0.9999069,0.00002089155,0.00002913157,0.000005952519,0.00002409476,0.00001307993],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003071904,0.00008830942,0.0001349758,0.0001070705,0.000007267734,0.00007195427,0.00001911148,0.0002228424,0.9967225,0.00004216679,0.00004834634,0.002228278],"study_design_scores_gemma":[0.00001885071,0.001303684,0.0006876835,0.000004253099,0.00002161342,0.00008892122,0.000010782,0.0007843421,0.9963332,0.00001874134,0.00072365,0.000004259613],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913913,0.002332483,0.004302847,0.0001025283,0.00003558944,0.00006170963,0.0001703434,0.00005625032,0.001546945],"genre_scores_gemma":[0.9920589,0.002031268,0.004239326,0.00004961895,0.00001220301,0.00005255685,0.0001956299,0.00001541876,0.001345103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004425168,"threshold_uncertainty_score":0.001380324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08709182090171448,"score_gpt":0.4310344809945169,"score_spread":0.3439426600928024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}