{"id":"W3091031035","doi":"10.1007/s00401-020-02226-7","title":"Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology","year":2020,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":168,"is_retracted":false,"has_abstract":true,"ca_institutions":"Delmar (Canada)","funders":"Helmholtz Zentrum München; Deutsche Forschungsgemeinschaft; H2020 Marie Skłodowska-Curie Actions; International Council for Canadian Studies; European Commission; Fonds De La Recherche Scientifique - FNRS; Fonds National de la Recherche Luxembourg; Fondation Cancer","keywords":"Organoid; Medicine; Oncology; Pathology; Internal medicine; Medical physics; Psychology; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004951955,0.0003554662,0.0004167741,0.0003494744,0.0002897766,0.0004990225,0.0002556542,0.000378913,0.002190164],"category_scores_gemma":[0.0002270406,0.0001858598,0.0004108218,0.000270248,0.000232107,0.0002884521,0.0005205895,0.001029712,0.0008932264],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002905409,"about_ca_system_score_gemma":0.0003065317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000656193,"about_ca_topic_score_gemma":0.001791326,"domain_scores_codex":[0.9996959,0.00005652457,0.00002931069,0.00007691102,0.00009635963,0.00004497875],"domain_scores_gemma":[0.999709,0.00004582237,0.0000445968,0.000103607,0.00003007779,0.00006694633],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000448087,0.0003481686,0.008313421,0.0000909314,0.00005956891,0.0005246035,0.0002144662,0.0008980336,0.9793448,0.0007756432,0.0009897989,0.007992496],"study_design_scores_gemma":[0.0000950546,0.003691199,0.04406365,0.00004057322,0.0001737057,0.008988328,0.0005698788,0.004385799,0.9025531,0.0005071259,0.03488525,0.0000464742],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9691452,0.0009038531,0.02095283,0.000136759,0.00007914141,0.0004140944,0.0044686,0.0002408511,0.003658597],"genre_scores_gemma":[0.9694189,0.0008947887,0.01479554,0.0001333702,0.0000136566,0.0004935177,0.00978089,0.0000891809,0.004380112],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002190164,"threshold_uncertainty_score":0.007326841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03236227331800066,"score_gpt":0.2670577288253949,"score_spread":0.2346954555073942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}