{"id":"W3091048385","doi":"10.3390/ijms21197222","title":"Modular Chimeric Antigen Receptor Systems for Universal CAR T Cell Retargeting","year":2020,"lang":"en","type":"review","venue":"International Journal of Molecular Sciences","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Western Economic Diversification Canada","keywords":"Chimeric antigen receptor; Modular design; Antigen; Cancer immunotherapy; T cell; Immunotherapy; Computer science; Retargeting; Biology; Cell biology; Immune system; Immunology; Artificial intelligence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001255286,0.0002464045,0.001104108,0.0005717649,0.00009301875,0.0001252398,0.001163729,0.00013848,0.0001843756],"category_scores_gemma":[0.0002635182,0.0001859008,0.000863836,0.0004422703,0.0001792871,0.0001281388,0.0001178531,0.0005096184,0.00002180892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003765115,"about_ca_system_score_gemma":0.001824831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001808076,"about_ca_topic_score_gemma":1.304626e-7,"domain_scores_codex":[0.9966403,0.0002261534,0.000820998,0.0003349851,0.001693356,0.000284169],"domain_scores_gemma":[0.9975725,0.0002019361,0.001000243,0.0001389523,0.0008719664,0.0002143314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003203835,0.0001992401,0.0000728091,0.006050766,0.00329736,0.002565192,0.0004513583,0.0004503349,0.04359737,0.0004607139,0.002118128,0.9404163],"study_design_scores_gemma":[0.0005249618,0.0004959417,0.000001032144,0.004151223,0.0002427577,0.0004440589,0.0001627049,0.0004856074,0.000366922,0.00001062902,0.9929549,0.0001593287],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000547408,0.9927418,0.002381316,0.0003290624,0.001861257,0.0006736324,0.00003386584,0.0000107139,0.001421004],"genre_scores_gemma":[0.000405588,0.9951583,0.002493145,0.00006903426,0.001130087,0.00001106375,0.00002465822,0.00003887398,0.0006692689],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9908367,"threshold_uncertainty_score":0.7580816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05421557644285135,"score_gpt":0.371786626070691,"score_spread":0.3175710496278396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}