{"id":"W3091048385","doi":"10.3390/ijms21197222","title":"Modular Chimeric Antigen Receptor Systems for Universal CAR T Cell Retargeting","year":2020,"lang":"en","type":"review","venue":"International Journal of Molecular Sciences","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Western Economic Diversification Canada","keywords":"Chimeric antigen receptor; Modular design; Antigen; Cancer immunotherapy; T cell; Immunotherapy; Computer science; Retargeting; Biology; Cell biology; Immune system; Immunology; Artificial intelligence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003192922,0.000618676,0.0006394638,0.001085649,0.0001306382,0.0004394836,0.0005249265,0.0006554842,0.002589351],"category_scores_gemma":[0.0002218521,0.0001999096,0.0004322154,0.000871005,0.0002575164,0.0007104587,0.0004189718,0.00117345,0.001902128],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003882637,"about_ca_system_score_gemma":0.0004291731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003902778,"about_ca_topic_score_gemma":0.0003817272,"domain_scores_codex":[0.9998679,0.00001889678,0.000009130222,0.00003186636,0.00005150777,0.00002063631],"domain_scores_gemma":[0.9999458,0.00001640131,0.00001246221,0.000003127219,0.00001433678,0.000007917961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001395015,0.0001931485,0.0001427648,0.0125549,0.00009414367,0.0003934545,0.0001031281,0.001742772,0.0937245,0.02061298,0.01683672,0.8534619],"study_design_scores_gemma":[0.00003592271,0.0004615515,0.0003781837,0.0007415828,0.00009512059,0.001234331,0.00003201876,0.0006589405,0.02765416,0.002041499,0.9666296,0.00003697878],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005008879,0.976366,0.008867871,0.0003640379,0.0005466146,0.00009073129,0.0001205901,0.0001591896,0.008476017],"genre_scores_gemma":[0.02493707,0.9613521,0.006802884,0.0004633018,0.0001678464,0.0001181984,0.0002765955,0.00002202025,0.005860053],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002589351,"threshold_uncertainty_score":0.008662224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05421557644285135,"score_gpt":0.371786626070691,"score_spread":0.3175710496278396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}