{"id":"W3091049434","doi":"10.1016/j.cellimm.2020.104220","title":"Building a CAR-Treg: Going from the basic to the luxury model","year":2020,"lang":"en","type":"review","venue":"Cellular Immunology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; University of British Columbia; BC Children's Hospital; Health Research","keywords":"Chimeric antigen receptor; Biology; Context (archaeology); Immunology; Autoimmunity; Immune system; Transplantation; Cell therapy; Function (biology); T cell; Stem cell; Cell biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0006850745,0.0006462589,0.00219113,0.0001800445,0.0002949224,0.00008386975,0.001618457,0.0006004454,0.001196881],"category_scores_gemma":[0.000384719,0.0003603499,0.001000702,0.0007836323,0.0002837228,0.0000333959,0.0009919825,0.002595386,0.001519382],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004705739,"about_ca_system_score_gemma":0.001011868,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001768765,"about_ca_topic_score_gemma":0.00002128893,"domain_scores_codex":[0.9962134,0.0008049178,0.0007423349,0.0009258459,0.0004837874,0.0008297503],"domain_scores_gemma":[0.9961641,0.001108021,0.0002334079,0.002232505,0.00008556322,0.0001764091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009980745,0.00003624091,0.000001486296,0.0008218436,0.001378275,0.0002428185,0.0006303709,0.00001110717,0.008615305,0.0004336809,0.004450725,0.9832783],"study_design_scores_gemma":[0.000418252,0.0001416091,0.000001125684,0.002699651,0.001117728,0.0001466778,0.00007693307,0.0006008344,0.0002898414,0.0001337298,0.9940602,0.0003134871],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001618654,0.9873311,0.002007466,0.005836422,0.00062795,0.002461193,0.00007004437,0.0001100439,0.001393914],"genre_scores_gemma":[0.00006762864,0.9878225,0.0005732181,0.001034212,0.001178043,0.000370188,0.0001950969,0.0002191237,0.008539932],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9896094,"threshold_uncertainty_score":0.9998848,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0708255561848193,"score_gpt":0.3463474842095065,"score_spread":0.2755219280246872,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}