{"id":"W3091049434","doi":"10.1016/j.cellimm.2020.104220","title":"Building a CAR-Treg: Going from the basic to the luxury model","year":2020,"lang":"en","type":"review","venue":"Cellular Immunology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; University of British Columbia; BC Children's Hospital; Health Research","keywords":"Chimeric antigen receptor; Biology; Context (archaeology); Immunology; Autoimmunity; Immune system; Transplantation; Cell therapy; Function (biology); T cell; Stem cell; Cell biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001967665,0.001027391,0.001712924,0.00115555,0.0004230036,0.002312162,0.001352117,0.00267378,0.004595327],"category_scores_gemma":[0.001322039,0.0003336533,0.000512996,0.0008873246,0.00144971,0.004071584,0.001332839,0.007327511,0.002719509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001279121,"about_ca_system_score_gemma":0.001720774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007557297,"about_ca_topic_score_gemma":0.001989901,"domain_scores_codex":[0.9996067,0.0001190949,0.00002976223,0.00006140544,0.0001250192,0.00005811439],"domain_scores_gemma":[0.9993057,0.0004321949,0.00004259529,0.00002024566,0.0001107298,0.00008835011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001698357,0.0001140906,0.0001466056,0.01061805,0.00008156143,0.0002000598,0.00008238108,0.0006280972,0.002381956,0.04483478,0.1066124,0.8341301],"study_design_scores_gemma":[0.00003138486,0.00008465989,0.0001165922,0.001827747,0.00003858604,0.0003412949,0.00005308304,0.0001265533,0.0003091378,0.0118079,0.9852495,0.00001350892],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007660389,0.9943677,0.000533598,0.002863998,0.001064623,0.000004810114,0.0000154358,0.00001568507,0.001057553],"genre_scores_gemma":[0.001689222,0.990311,0.000832821,0.004223735,0.001381152,0.00002117881,0.00004362721,0.000008916001,0.001488438],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004595327,"threshold_uncertainty_score":0.01537293,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0708255561848193,"score_gpt":0.3463474842095065,"score_spread":0.2755219280246872,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}