{"id":"W3091090497","doi":"10.21203/rs.3.rs-34021/v5","title":"Metadichol®, a Novel Nano Lipid Formulation that Inhibits SARS-COV-2 and a Multitude of Pathological Viruses in vitro","year":2020,"lang":"en","type":"preprint","venue":"Research Square","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"NanoXplore (Canada)","funders":"","keywords":"Viral envelope; Virus; Infectivity; In vitro; Serine protease; Virology; TMPRSS2; Biology; Coronavirus; Lipid bilayer; Lipid bilayer fusion; Viral entry; Proteases; Protease; Microbiology; Chemistry; Viral replication; Biochemistry; Coronavirus disease 2019 (COVID-19); Membrane; Medicine; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001877237,0.0003400189,0.0001988471,0.000269836,0.00009681535,0.0002131945,0.0001991102,0.0003107186,0.002084579],"category_scores_gemma":[0.0001290593,0.0001133427,0.0002381856,0.0001301571,0.000124835,0.0002983317,0.0001884381,0.0004441396,0.0004973855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001595195,"about_ca_system_score_gemma":0.0002457966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000297601,"about_ca_topic_score_gemma":0.0005012588,"domain_scores_codex":[0.9999231,0.0000125433,0.000006315423,0.00001732707,0.00002901611,0.00001170424],"domain_scores_gemma":[0.9999642,0.000007049592,0.00001004902,0.000003905668,0.000006458516,0.000008408708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003877888,0.00009596707,0.00008257225,0.0001438716,0.00001268572,0.00006935478,0.00001686225,0.0001297663,0.9813005,0.0002311667,0.0002855408,0.01724397],"study_design_scores_gemma":[0.0001760477,0.001985539,0.001075509,0.00002096231,0.00004629332,0.0004918881,0.00001659481,0.000655818,0.9817801,0.00008935032,0.01365182,0.00001010619],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9445516,0.01671381,0.02203118,0.0008059926,0.0006357765,0.0004110479,0.001396235,0.0003554234,0.01309902],"genre_scores_gemma":[0.9626229,0.007548251,0.01754993,0.0003354193,0.0001162148,0.0001544426,0.0013141,0.00005329255,0.01030545],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002084579,"threshold_uncertainty_score":0.006973624,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2561718149435424,"score_gpt":0.4616410523559741,"score_spread":0.2054692374124317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}