{"id":"W3091166611","doi":"10.1007/s40744-020-00236-1","title":"Repository Corticotropin Injection for Persistently Active Systemic Lupus Erythematosus: Results from a Phase 4, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial","year":2020,"lang":"en","type":"article","venue":"Rheumatology and Therapy","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Mallinckrodt Pharmaceuticals","keywords":"Medicine; Placebo; Prednisone; Internal medicine; Adverse effect; Rash; Glucocorticoid; Randomized controlled trial; Population; Gastroenterology; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006012256,0.0003999217,0.002553777,0.0001861708,0.0002661384,0.00005907581,0.0001683309,0.0004106831,0.00002687087],"category_scores_gemma":[0.0009706558,0.0002910792,0.0005960844,0.0001553476,0.0003051425,0.0001279476,0.00004159364,0.0003722615,0.00001854264],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000104942,"about_ca_system_score_gemma":0.000252493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002058001,"about_ca_topic_score_gemma":0.000005081011,"domain_scores_codex":[0.9960546,0.0007862184,0.001493632,0.000821855,0.0003725335,0.0004711577],"domain_scores_gemma":[0.9954255,0.002767468,0.0007568652,0.0004228653,0.0002903446,0.0003369476],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9816453,0.0006229306,0.0009134886,0.0003889193,0.002917839,0.00005340364,0.01045687,0.000003666365,0.001851345,0.0001506489,0.0003691672,0.0006263623],"study_design_scores_gemma":[0.9738135,0.002669897,6.340253e-7,0.0005845774,0.0003880079,0.009687577,0.004112748,0.00715316,0.001113752,0.00004602229,0.000194165,0.0002359129],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9709738,0.006304962,0.001059008,0.0009957526,0.00155136,0.01863872,0.0000600643,0.0001711415,0.0002451418],"genre_scores_gemma":[0.9936845,0.002091595,0.0001601072,0.000208764,0.0002591321,0.003070426,0.0001271851,0.00006115624,0.0003371445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02271064,"threshold_uncertainty_score":0.9999542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04255996117976809,"score_gpt":0.3214453549871027,"score_spread":0.2788853938073347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}