{"id":"W3091209026","doi":"10.1093/ehjcvp/pvaa118","title":"REDUCE-IT INTERIM: accumulation of data across prespecified interim analyses to final results","year":2020,"lang":"en","type":"letter","venue":"European Heart Journal - Cardiovascular Pharmacotherapy","topic":"Fatty Acid Research and Health","field":"Nursing","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"","keywords":"Interim; Interim analysis; Environmental science; Medicine; Political science; Clinical trial; Internal medicine; Law","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.005485685,0.0007809445,0.001789812,0.0005436612,0.0005411985,0.0006563984,0.00292322,0.0002590398,0.0003437225],"category_scores_gemma":[0.0005372343,0.0007173951,0.002085597,0.0008042023,0.0002120554,0.0007673029,0.0007500777,0.005818478,0.0004317466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003061333,"about_ca_system_score_gemma":0.0002470585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001178213,"about_ca_topic_score_gemma":0.000004049781,"domain_scores_codex":[0.9864165,0.006284004,0.002041906,0.001470683,0.002451725,0.001335203],"domain_scores_gemma":[0.9951444,0.0002645657,0.0006617352,0.002604271,0.000588653,0.0007363388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004595373,0.00007419672,0.000007979976,0.0003033425,0.002941347,0.001881652,0.001637796,0.0004865839,0.04834489,3.733892e-8,0.9043846,0.03534219],"study_design_scores_gemma":[0.004041053,0.0008877382,0.0004256247,0.0008007221,0.000360137,0.0007783474,0.00009992016,0.0003645644,0.01925714,0.000005052479,0.9723546,0.0006251283],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.006259291,0.01418105,0.006674808,0.957094,0.009228675,0.002098167,0.002254763,0.0002589563,0.001950264],"genre_scores_gemma":[0.03143779,0.006785149,0.01083953,0.8797067,0.06713358,0.00001852794,0.001788861,0.000978517,0.001311293],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.07738728,"threshold_uncertainty_score":0.9995277,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.6569511246349635,"score_gpt":0.5574347546978977,"score_spread":0.09951636993706581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}