{"id":"W3091309223","doi":"10.1200/po.20.00050","title":"Intratumoral Transcriptome Heterogeneity Is Associated With Patient Prognosis and Sidedness in Patients With Colorectal Cancer Treated With Anti-EGFR Therapy From the CO.20 Trial","year":2020,"lang":"en","type":"article","venue":"JCO Precision Oncology","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Ottawa Hospital","funders":"Rosetrees Trust; National Institute for Health and Care Research; Cancer Research UK","keywords":"Medicine; Internal medicine; Hazard ratio; Cetuximab; Colorectal cancer; Oncology; Odds ratio; Cohort; Epidermal growth factor receptor; Univariate analysis; Progression-free survival; Multivariate analysis; Cancer; Overall survival; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00104583,0.0002119741,0.0006137377,0.0001746615,0.0002024637,0.0005843262,0.0001869139,0.0002864368,0.00079016],"category_scores_gemma":[0.001062673,0.0001350264,0.0003641727,0.0002431425,0.0002416935,0.0002176934,0.0002917061,0.00047109,0.0001237436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002588269,"about_ca_system_score_gemma":0.0002133966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000224554,"about_ca_topic_score_gemma":0.0006142292,"domain_scores_codex":[0.9995854,0.0001433393,0.00003199187,0.0001187534,0.00006827528,0.0000522732],"domain_scores_gemma":[0.9988444,0.0003042994,0.0004816849,0.0001028289,0.0000910435,0.0001757609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.06692692,0.0006648039,0.8412678,0.0002095848,0.001068652,0.0002176757,0.0001471447,0.001023731,0.05492209,0.0001115892,0.001186136,0.03225385],"study_design_scores_gemma":[0.001078486,0.005721678,0.9824182,0.00001540915,0.0007059447,0.0004624826,0.00009134578,0.00180893,0.005550834,0.0001596733,0.001966116,0.0000208981],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987956,0.0004644436,0.0001110776,0.0000531545,0.000009395668,0.00001299914,0.0002652488,0.000003705327,0.000284348],"genre_scores_gemma":[0.998689,0.0001179077,0.0001007895,0.0000550658,0.00001964782,0.00002332171,0.0007914584,0.000003271032,0.000199565],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00104583,"threshold_uncertainty_score":0.005530894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03191056901264257,"score_gpt":0.3015779267844678,"score_spread":0.2696673577718252,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}