{"id":"W3091445120","doi":"10.1016/j.bpsc.2020.09.014","title":"A Novel Biomarker of Neuronal Glutamate Metabolism in Nonhuman Primates Using Localized 1H-Magnetic Resonance Spectroscopy: Development and Effects of BNC375, an α7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulator","year":2020,"lang":"en","type":"article","venue":"Biological Psychiatry Cognitive Neuroscience and Neuroimaging","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute on Alcohol Abuse and Alcoholism; Johnson and Johnson; National Institutes of Health; Vistagen Therapeutics; Taiho Pharmaceutical; F. Hoffmann-La Roche; Valeant Pharmaceuticals International; Merck; Teva Pharmaceutical Industries; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Allosteric regulation; Glutamate receptor; Allosteric modulator; Neuroscience; Nicotinic acetylcholine receptor; Biomarker; Nicotinic agonist; Chemistry; Nuclear magnetic resonance; Biology; Receptor; Biochemistry; Physics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003516291,0.0005999783,0.0004628052,0.000342681,0.0004875942,0.0003511668,0.0004226476,0.0008050424,0.0004997613],"category_scores_gemma":[0.0003236552,0.0002226487,0.0001471277,0.0002812419,0.0005390447,0.0003854531,0.0002089765,0.0005906961,0.0001316671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004236452,"about_ca_system_score_gemma":0.0005521896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003751466,"about_ca_topic_score_gemma":0.01228542,"domain_scores_codex":[0.9998751,0.00004374663,0.000004096766,0.00003690467,0.00002677444,0.00001342268],"domain_scores_gemma":[0.9998866,0.00001532706,0.00003034899,0.00001200424,0.00002574672,0.00002993786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002600317,0.000371716,0.009873933,0.000251199,0.0001543907,0.0004326031,0.0001191379,0.0002867068,0.9502351,0.0003679515,0.0006526589,0.03465424],"study_design_scores_gemma":[0.0005048341,0.01519361,0.1375763,0.00009359332,0.001053346,0.005284796,0.0005846265,0.01065055,0.8159387,0.002008245,0.01100436,0.0001071235],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9605486,0.01044867,0.0241467,0.0005839357,0.00008289966,0.0004151229,0.0007746744,0.0002829451,0.002716437],"genre_scores_gemma":[0.9608519,0.005932742,0.0284754,0.0005957214,0.00003926269,0.0004318725,0.0007468035,0.0000519564,0.002874288],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003751466,"threshold_uncertainty_score":0.007459223,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03269330034001526,"score_gpt":0.2949418071392285,"score_spread":0.2622485067992132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}