{"id":"W3091517598","doi":"10.1016/j.pharmthera.2020.107703","title":"Can N-3 polyunsaturated fatty acids be considered a potential adjuvant therapy for COVID-19-associated cardiovascular complications?","year":2020,"lang":"en","type":"review","venue":"Pharmacology & Therapeutics","topic":"Eicosanoids and Hypertension Pharmacology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Innovates","keywords":"Polyunsaturated fatty acid; Eicosapentaenoic acid; Docosahexaenoic acid; Medicine; Oxidative stress; Adjuvant; Coronavirus disease 2019 (COVID-19); Coagulopathy; Coronavirus; Adjuvant therapy; Immune system; Immunology; Disease; Pharmacology; Internal medicine; Fatty acid; Infectious disease (medical specialty); Biology; Biochemistry; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004909871,0.001000048,0.002585777,0.0001754197,0.0005427336,0.00005934115,0.0008617953,0.001287005,0.0001266181],"category_scores_gemma":[0.00005294593,0.0008916689,0.001977329,0.0003720803,0.0004872222,0.000006032049,0.0002503081,0.000751436,0.00001496535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002015858,"about_ca_system_score_gemma":0.002374811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002479772,"about_ca_topic_score_gemma":0.00001351461,"domain_scores_codex":[0.9951409,0.0013017,0.0009909862,0.00139863,0.0002779576,0.0008897908],"domain_scores_gemma":[0.9974163,0.0002243374,0.0006455354,0.000690001,0.0004506639,0.0005731834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001497416,0.001690702,0.00002562369,0.002901176,0.07925484,0.0003423957,0.0002804913,0.0001540846,0.1748838,0.00008422542,0.09338937,0.6454958],"study_design_scores_gemma":[0.004707276,0.0005750736,0.000006860857,0.00006040604,0.009984061,0.0002072337,0.00002495543,0.0001606793,0.001993967,0.00004985138,0.9813449,0.0008846694],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002427669,0.9835004,0.001148449,0.007487392,0.001318716,0.003717748,0.002417134,0.0001413951,0.00002597477],"genre_scores_gemma":[0.002348559,0.9231804,0.0002555564,0.06664767,0.0007119764,0.001191037,0.005366917,0.0002121443,0.00008571473],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8879556,"threshold_uncertainty_score":0.9993534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.125277406399098,"score_gpt":0.3917818565892979,"score_spread":0.2665044501901999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}