{"id":"W3091601571","doi":"10.1016/j.bbadis.2020.165982","title":"Glutaredoxin-2 and Sirtuin-3 deficiencies impair cardiac mitochondrial energetics but their effects are not additive","year":2020,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research; Nasjonalforeningen for Folkehelsen","keywords":"SIRT3; Sirtuin; Oxidative stress; Mitochondrion; Glutaredoxin; Endocrinology; Internal medicine; SIRT2; Mitochondrial ROS; Knockout mouse; Biology; Chemistry; Cell biology; NAD+ kinase; Medicine; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003203163,0.0008544213,0.0009816885,0.0005161456,0.0002596116,0.000589395,0.000666844,0.0008423669,0.003017765],"category_scores_gemma":[0.0002891283,0.0004023393,0.0009201224,0.0003400957,0.0006838284,0.0006763358,0.000754543,0.001246857,0.0005240551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004464664,"about_ca_system_score_gemma":0.0005594118,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001418511,"about_ca_topic_score_gemma":0.003064135,"domain_scores_codex":[0.9996233,0.00005894414,0.00005960126,0.00007605267,0.00008142424,0.0001007016],"domain_scores_gemma":[0.999566,0.00005327653,0.00008965178,0.00007939345,0.00003307207,0.0001785128],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003958393,0.0001572012,0.0005974718,0.00008412491,0.000159311,0.0002510182,0.00003054416,0.0001206144,0.991353,0.0003442092,0.0001848168,0.002759286],"study_design_scores_gemma":[0.0006454834,0.003452922,0.02355122,0.00003395429,0.000524317,0.001401292,0.0002965368,0.001211866,0.9618295,0.0009458557,0.006053338,0.00005356445],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987267,0.004033399,0.003232368,0.000575623,0.0003670041,0.00005385494,0.0008909661,0.0003293294,0.00325047],"genre_scores_gemma":[0.9941016,0.0010622,0.001294827,0.0002310711,0.00003302533,0.00003049835,0.0004442872,0.00004254353,0.002759953],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003017765,"threshold_uncertainty_score":0.01009542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008998951504834735,"score_gpt":0.2271864721690733,"score_spread":0.2181875206642385,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}