{"id":"W3091838362","doi":"10.1002/jcp.30065","title":"TRIM4 interacts with TRPM8 and regulates its channel function through K423‐mediated ubiquitination","year":2020,"lang":"en","type":"article","venue":"Journal of Cellular Physiology","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Natural Science Foundation of China","keywords":"TRPM8; Ubiquitin; Ubiquitin ligase; Transient receptor potential channel; HEK 293 cells; Cell biology; Chemistry; Gene knockdown; Biochemistry; Receptor; Biology; Gene; TRPV1","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001124441,0.0002938366,0.0002077291,0.0002611492,0.0003678863,0.0002446938,0.0002761924,0.000315387,0.001398119],"category_scores_gemma":[0.0001351206,0.0001232605,0.0003638369,0.0001713268,0.0001953788,0.0002615923,0.0003453765,0.0004257674,0.0006737389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004546237,"about_ca_system_score_gemma":0.0001836082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000537068,"about_ca_topic_score_gemma":0.0006326112,"domain_scores_codex":[0.9998578,0.00002945269,0.00001073132,0.00002822633,0.00003377187,0.0000400092],"domain_scores_gemma":[0.999944,0.000004652492,0.00001906709,0.00000713539,0.00001066657,0.00001455692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001318214,0.00001761186,0.0006089295,0.00004893065,0.00001180579,0.0001571439,0.00001294196,0.0000708976,0.9965667,0.0001792829,0.0001559468,0.002038009],"study_design_scores_gemma":[0.00002998815,0.0001506053,0.02440955,0.00001393201,0.0000450641,0.001222574,0.0000923543,0.003483762,0.9615996,0.0002580441,0.008682382,0.00001217471],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9858969,0.003992829,0.006242044,0.0002056636,0.00006410508,0.00002038681,0.0002877027,0.0002023992,0.003088018],"genre_scores_gemma":[0.9900383,0.001338796,0.002496321,0.0001126921,0.00001659985,0.00003221978,0.0006438919,0.000030436,0.005290844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001398119,"threshold_uncertainty_score":0.004677176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03457167168637478,"score_gpt":0.2329302601582288,"score_spread":0.198358588471854,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}