{"id":"W3091858640","doi":"10.1080/14756366.2020.1825408","title":"Design of new disubstituted imidazo[1,2-<i>b</i>]pyridazine derivatives as selective Haspin inhibitors. Synthesis, binding mode and anticancer biological evaluation","year":2020,"lang":"en","type":"article","venue":"Journal of Enzyme Inhibition and Medicinal Chemistry","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Meso Scale Diagnostics; Janssen Biotech; Innovative Medicines Initiative; Ministero dello Sviluppo Economico; Région Bretagne; Labex; AbbVie; Novartis Pharma; Deutschen Konsortium für Translationale Krebsforschung; Canada Foundation for Innovation; Ontario Ministry of Economic Development and Innovation; Agence Nationale de la Recherche; Wellcome Trust; Cancéropôle Grand Ouest; Fundação de Amparo à Pesquisa do Estado de São Paulo; Diamond Light Source; Genome Canada; Takeda Pharmaceutical Company; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Pfizer; Ligue Contre le Cancer; Boehringer Ingelheim","keywords":"Pyridazine; Chemistry; Stereochemistry; Combinatorial chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001041115,0.0004812177,0.000392067,0.0001833225,0.0001135099,0.000280452,0.0004257547,0.0002464229,0.001361372],"category_scores_gemma":[0.0001069957,0.0001772645,0.0001420941,0.0002532064,0.0001730182,0.0002667283,0.0001965704,0.0003729686,0.0003796311],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003491913,"about_ca_system_score_gemma":0.000338339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005653301,"about_ca_topic_score_gemma":0.001864304,"domain_scores_codex":[0.9999498,0.000007221842,0.000004928063,0.00001213972,0.00001016372,0.00001578283],"domain_scores_gemma":[0.9999654,0.000002490857,0.00001079139,0.000003013195,0.000007545812,0.0000106989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006457669,0.0002356827,0.0002952734,0.0007810886,0.00004127756,0.0005228206,0.00008016002,0.003213564,0.9549008,0.002810392,0.001431527,0.03504153],"study_design_scores_gemma":[0.0005656342,0.00425508,0.001592208,0.00005845041,0.0001179729,0.001016522,0.00003894907,0.006385552,0.9486011,0.0003652029,0.03694798,0.00005541822],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8944229,0.01974576,0.05704405,0.0007110112,0.0003027984,0.001787085,0.002432152,0.0008978223,0.02265638],"genre_scores_gemma":[0.9642304,0.00821319,0.01934978,0.0002196597,0.00003014274,0.0003375697,0.00111766,0.00003072544,0.006470839],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001361372,"threshold_uncertainty_score":0.004554212,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07055397884432821,"score_gpt":0.3443127778255069,"score_spread":0.2737587989811787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}