{"id":"W3091905709","doi":"10.1101/2020.10.06.327825","title":"Transmembrane polar relay drives the allosteric regulation for ABCG5/G8 sterol transporter","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Institutes of Health; University of Ottawa; Heart and Stroke Foundation of Canada","keywords":"Missense mutation; Sterol; Biology; ATP-binding cassette transporter; Transmembrane protein; Transmembrane domain; Loss function; Allosteric regulation; Cell biology; Biochemistry; Transporter; Mutation; Chemistry; Cholesterol; Phenotype; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001076751,0.0002267801,0.0001437363,0.0001054813,0.0001084148,0.0001961379,0.0002026791,0.0003116805,0.00108359],"category_scores_gemma":[0.0001729315,0.00007538402,0.0001439842,0.00006783536,0.0003781922,0.0001133163,0.0002405819,0.0002257202,0.0004525052],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003028582,"about_ca_system_score_gemma":0.0001080342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005110401,"about_ca_topic_score_gemma":0.000423429,"domain_scores_codex":[0.9999026,0.00002408627,0.000009506653,0.00001996668,0.0000298581,0.00001403953],"domain_scores_gemma":[0.99992,0.00001616597,0.00002571545,0.00001116629,0.00001118485,0.0000156877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004240234,0.000004304874,0.0003084396,0.000008649552,0.000001614528,0.00006102514,0.000006700986,0.00003609198,0.9990448,0.000128885,0.00002004732,0.0003369554],"study_design_scores_gemma":[0.00002643999,0.00007778026,0.005250641,0.000005441058,0.00001049465,0.0003921496,0.00004311715,0.004321204,0.9881577,0.0001946064,0.001514325,0.000006095969],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973572,0.0002342657,0.00165774,0.0001105746,0.00001560913,0.000007437767,0.0000647756,0.00006054361,0.0004919176],"genre_scores_gemma":[0.9991426,0.00003720443,0.0005036503,0.00001894874,0.000002588592,0.000003534206,0.00003723407,0.000006073096,0.0002480935],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00108359,"threshold_uncertainty_score":0.003624916,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01904919955609606,"score_gpt":0.2304782639518024,"score_spread":0.2114290643957063,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}