{"id":"W3091922136","doi":"10.1016/j.mad.2020.111382","title":"Autophagy and heat-shock response impair stress granule assembly during cellular senescence","year":2020,"lang":"en","type":"article","venue":"Mechanisms of Ageing and Development","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; McGill University","keywords":"Autophagy; Senescence; Heat shock; Cell biology; Cellular Aging; Granule (geology); Heat stress; Ageing; Biology; Heat shock protein; Cellular senescence; Fight-or-flight response; Shock (circulatory); Chemistry; Biochemistry; Telomere; Medicine; Genetics; Internal medicine; Phenotype; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003883964,0.000317231,0.0004932149,0.0002771005,0.0002275429,0.0004892628,0.000215801,0.0004798362,0.002079469],"category_scores_gemma":[0.0002851254,0.0002668198,0.0005257487,0.0001989269,0.0003559359,0.0005430125,0.0004070082,0.0007724859,0.0004547046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003358022,"about_ca_system_score_gemma":0.0003115512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003324271,"about_ca_topic_score_gemma":0.0005169043,"domain_scores_codex":[0.9997175,0.0000625816,0.00004416724,0.00003269042,0.00003658727,0.0001063731],"domain_scores_gemma":[0.999741,0.00004661396,0.00007128137,0.00004422366,0.00002346766,0.00007338476],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001711776,0.00007011138,0.0002057309,0.00005413139,0.00001798896,0.00006064013,0.00003181702,0.00005425771,0.9961532,0.0003608236,0.00008822464,0.001191388],"study_design_scores_gemma":[0.00006052281,0.0006114179,0.01008924,0.00001034476,0.00002699586,0.0002485976,0.00006024777,0.0006103561,0.9863251,0.000260001,0.001687629,0.000009499095],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934953,0.002540319,0.002118968,0.0001871755,0.00008197105,0.00002483934,0.0002682112,0.00009314572,0.001189982],"genre_scores_gemma":[0.9961532,0.0006277337,0.0008569189,0.00009521744,0.00001795277,0.00003310677,0.000325961,0.00001910104,0.001870818],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002079469,"threshold_uncertainty_score":0.006956458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01299165488957906,"score_gpt":0.2317290445343022,"score_spread":0.2187373896447231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}