{"id":"W3091933145","doi":"10.1016/j.jtocrr.2020.100103","title":"JNJ-64041757 (JNJ-757), a Live, Attenuated, Double-Deleted Listeria monocytogenes–Based Immunotherapy in Patients With NSCLC: Results From Two Phase 1 Studies","year":2020,"lang":"en","type":"article","venue":"JTO Clinical and Research Reports","topic":"Listeria monocytogenes in Food Safety","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"EMD Serono; Johnson and Johnson; Genentech; Astellas Pharma; Eisai; Daiichi-Sankyo; Pfizer; Incyte; Pharmaceuticals Bayer; Syndax Pharmaceuticals; Clovis Oncology; Bayer Fund; AstraZeneca; Canadian Asian Studies Association; Novocure; Exelixis; Takeda Pharmaceuticals U.S.A.; Spectrum Pharmaceuticals; Merck; University of Michigan; AbbVie; Roche; Novartis; Celgene; Eli Lilly and Company; Bristol-Myers Squibb; Boehringer Ingelheim; Amgen","keywords":"Chills; Medicine; Nivolumab; Internal medicine; Gastroenterology; Combination therapy; Adverse effect; Immunotherapy; Phases of clinical research; Surgery; Cancer; Chemotherapy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001755756,0.0007911963,0.001176036,0.0002438607,0.0003093884,0.0006207612,0.0004799736,0.0007265087,0.001222114],"category_scores_gemma":[0.0004399884,0.00025985,0.0008089584,0.000213974,0.0004783465,0.0003797832,0.0002224149,0.001083752,0.0003733038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001133642,"about_ca_system_score_gemma":0.00140769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0016163,"about_ca_topic_score_gemma":0.00627214,"domain_scores_codex":[0.9996448,0.0001207556,0.00003130283,0.00006206709,0.00007576567,0.00006532195],"domain_scores_gemma":[0.9996276,0.00004434559,0.00007203274,0.00002101228,0.00005551786,0.0001794933],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2393064,0.05407114,0.05148873,0.002903345,0.004907317,0.0006773424,0.0006149579,0.00314235,0.2205467,0.0003041491,0.009425674,0.412612],"study_design_scores_gemma":[0.2224674,0.5911852,0.1415997,0.0002612769,0.002982043,0.001271885,0.0002175549,0.002229178,0.0205169,0.0001511861,0.01701512,0.0001027186],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899113,0.007157262,0.0002831598,0.0003019828,0.000104069,0.0006193182,0.0004818059,0.00005171202,0.001089472],"genre_scores_gemma":[0.991154,0.003505925,0.0008875394,0.0008212422,0.0001026726,0.0003611345,0.002060426,0.00001509551,0.001091974],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001755756,"threshold_uncertainty_score":0.00928545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.312419106822627,"score_gpt":0.4891006084337852,"score_spread":0.1766815016111582,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}