{"id":"W3091939515","doi":"10.1136/bmj.m3434","title":"Association between FDA and EMA expedited approval programs and therapeutic value of new medicines: retrospective cohort study","year":2020,"lang":"en","type":"article","venue":"BMJ","topic":"Health Systems, Economic Evaluations, Quality of Life","field":"Economics, Econometrics and Finance","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences","keywords":"Medicine; Retrospective cohort study; Alternative medicine; Drug approval; Family medicine; Value (mathematics); Data science; Pharmacology; Computer science; Surgery; Drug; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002656065,0.0002912795,0.0005030351,0.001188476,0.0004952337,0.0008836965,0.0007868374,0.0006128664,0.002450144],"category_scores_gemma":[0.007688135,0.0004669631,0.00092225,0.001901362,0.0003411921,0.001001807,0.0005822626,0.0008520453,0.0004019578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005365029,"about_ca_system_score_gemma":0.0006836926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006072305,"about_ca_topic_score_gemma":0.006565907,"domain_scores_codex":[0.9975619,0.0004247091,0.0003643237,0.0007986695,0.0005649341,0.0002853673],"domain_scores_gemma":[0.9890659,0.001431627,0.006967942,0.001025992,0.0008675531,0.0006409715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002197139,0.00003498613,0.9987709,0.00001362635,0.0001060165,0.0000373842,0.00002585962,0.00003306014,0.00004724531,0.00003237472,0.0001870848,0.0004916994],"study_design_scores_gemma":[0.00003857124,0.0001754384,0.998354,0.00002347828,0.00009645658,0.0002656089,0.000144743,0.000318758,0.00007350792,0.00004254803,0.0004568945,0.00001009154],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956169,0.0004042613,0.0002641504,0.00004527756,0.00001429368,0.00005567461,0.002973928,0.000004654567,0.0006208536],"genre_scores_gemma":[0.9971232,0.0001470172,0.0001737556,0.00005523804,0.00001965659,0.00005813915,0.002169822,0.000004767612,0.0002484756],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006072305,"threshold_uncertainty_score":0.01404685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2864732381129127,"score_gpt":0.426380455733064,"score_spread":0.1399072176201513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}