{"id":"W3091952232","doi":"10.1167/tvst.9.11.9","title":"The RUSH2A Study: Best-Corrected Visual Acuity, Full-Field Electroretinography Amplitudes, and Full-Field Stimulus Thresholds at Baseline","year":2020,"lang":"en","type":"article","venue":"Translational Vision Science & Technology","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Spark Therapeutics; Moorfields Eye Hospital NHS Foundation Trust; National Eye Institute; Astellas Pharma; Alimera Sciences; Biogen; Agence Nationale de la Recherche; Sanofi; PTC Therapeutics; National Institute for Health and Care Research; Allergan; National Institutes of Health; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Regeneron Pharmaceuticals; NightstaRx; University of California, San Francisco; ProQR Therapeutics; Apellis Pharmaceuticals; Genentech; Research to Prevent Blindness","keywords":"Electroretinography; Ophthalmology; Usher syndrome; Retinitis pigmentosa; Medicine; Visual acuity; Audiology; Erg; Stimulus (psychology); Retinal degeneration; Internal medicine; Retinal; Psychology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001484456,0.0008193615,0.0006916002,0.0003885162,0.0004102501,0.000764043,0.0005350637,0.0008265628,0.001612049],"category_scores_gemma":[0.001930354,0.0003788343,0.0006606193,0.0005817919,0.0002381742,0.0005764689,0.0003827087,0.0006414393,0.0003430218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000197738,"about_ca_system_score_gemma":0.0002285751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001831535,"about_ca_topic_score_gemma":0.001807008,"domain_scores_codex":[0.9992839,0.0002877128,0.00005948212,0.0002313377,0.00008324823,0.00005440254],"domain_scores_gemma":[0.9987204,0.0001895898,0.0005554346,0.0001642873,0.0001156886,0.0002546644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004093019,0.0001319582,0.9919246,0.00003438634,0.0006303176,0.0001864225,0.00008608336,0.00006841292,0.001156243,0.00003024794,0.0002341692,0.001424204],"study_design_scores_gemma":[0.0003039861,0.0008452347,0.9970457,0.00001145431,0.0003013399,0.0006521064,0.00006784136,0.0002714659,0.0001625373,0.00003940149,0.0002920026,0.000006917561],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987369,0.0004902672,0.00009035268,0.00003194237,0.000006889108,0.00001480599,0.0004159229,0.000005684845,0.0002072865],"genre_scores_gemma":[0.9990369,0.00007711848,0.00009905845,0.00002939592,0.00002306324,0.0000215241,0.0004862557,0.000004917988,0.0002217665],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001831535,"threshold_uncertainty_score":0.007850647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01042787750571933,"score_gpt":0.3055258142222894,"score_spread":0.2950979367165701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}