{"id":"W3091952232","doi":"10.1167/tvst.9.11.9","title":"The RUSH2A Study: Best-Corrected Visual Acuity, Full-Field Electroretinography Amplitudes, and Full-Field Stimulus Thresholds at Baseline","year":2020,"lang":"en","type":"article","venue":"Translational Vision Science & Technology","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Spark Therapeutics; Moorfields Eye Hospital NHS Foundation Trust; National Eye Institute; Astellas Pharma; Alimera Sciences; Biogen; Agence Nationale de la Recherche; Sanofi; PTC Therapeutics; National Institute for Health and Care Research; Allergan; National Institutes of Health; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Regeneron Pharmaceuticals; NightstaRx; University of California, San Francisco; ProQR Therapeutics; Apellis Pharmaceuticals; Genentech; Research to Prevent Blindness","keywords":"Electroretinography; Ophthalmology; Usher syndrome; Retinitis pigmentosa; Medicine; Visual acuity; Audiology; Erg; Stimulus (psychology); Retinal degeneration; Internal medicine; Retinal; Psychology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000575179,0.0002064213,0.0001661948,0.0002156263,0.0007258213,0.00008535548,0.0005691781,0.0001982043,0.00004404167],"category_scores_gemma":[0.0003755575,0.0001579695,0.00006231761,0.001285702,0.0006181807,0.00001926833,0.0002760374,0.0002248412,0.0000124974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000962473,"about_ca_system_score_gemma":0.0001781169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006624085,"about_ca_topic_score_gemma":0.0001600453,"domain_scores_codex":[0.9980403,0.00004680336,0.0003241876,0.0006772624,0.0004964224,0.0004150209],"domain_scores_gemma":[0.9992354,0.0001178424,0.00008437841,0.0002439931,0.000189254,0.0001291135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001174682,0.0001917441,0.1063346,0.00000744134,0.00003874119,0.000005180401,0.000206784,0.00003756611,0.8410708,0.001043309,0.0009186485,0.04897049],"study_design_scores_gemma":[0.01118545,0.05075164,0.1446167,0.0001016672,0.0002937792,0.0003100923,0.00459561,0.0133014,0.6118424,0.01009793,0.1493426,0.003560781],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9689723,0.0008579102,0.0146538,0.01444074,0.00008769864,0.0004088923,0.000003992859,0.00006347631,0.0005111558],"genre_scores_gemma":[0.9981958,0.0002441319,0.0006201541,0.0007981386,0.00004285733,0.00002901918,0.00002258854,0.00001163841,0.00003570565],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2292285,"threshold_uncertainty_score":0.644181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01042787750571933,"score_gpt":0.3055258142222894,"score_spread":0.2950979367165701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}