{"id":"W3091966919","doi":"10.1136/bmjopen-2020-041359","title":"Vedolizumab treatment across antiretroviral treatment interruption in chronic HIV infection: the HAVARTI protocol for a pilot dose-ranging clinical trial to assess safety, tolerance, immunological and virological activity","year":2020,"lang":"en","type":"article","venue":"BMJ Open","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; Ottawa Hospital","funders":"Canadian HIV Trials Network, Canadian Institutes of Health Research; Canadian Institutes of Health Research; Health Canada; University of Ottawa","keywords":"Medicine; Antiretroviral treatment; Clinical trial; Human immunodeficiency virus (HIV); Dose-ranging study; Pilot trial; Immunology; Virology; Viral load; Antiretroviral therapy; Internal medicine; Randomized controlled trial; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01618224,0.004030527,0.003741995,0.001187718,0.002410885,0.002367368,0.002934409,0.004530371,0.02328178],"category_scores_gemma":[0.008356126,0.001579947,0.001890906,0.001272997,0.002627268,0.001681356,0.00146302,0.005993454,0.006474381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002622774,"about_ca_system_score_gemma":0.008923086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000939518,"about_ca_topic_score_gemma":0.002128807,"domain_scores_codex":[0.990418,0.006784722,0.0005664029,0.0006316808,0.0006569985,0.0009421306],"domain_scores_gemma":[0.9951025,0.0007620809,0.000871219,0.0009750483,0.0008334401,0.001455729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8614053,0.05084208,0.001930264,0.002729646,0.0005447073,0.000434426,0.000324718,0.00205278,0.02026583,0.003716665,0.01490101,0.04085247],"study_design_scores_gemma":[0.7071924,0.2347566,0.005919817,0.0005880796,0.0003147595,0.0002633873,0.00009680119,0.001195197,0.004935799,0.001533469,0.04310254,0.0001011336],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.05249824,0.001002301,0.004703749,0.0005728534,0.0004785807,0.9292217,0.003957253,0.0002452856,0.007319985],"genre_scores_gemma":[0.05250276,0.0005676924,0.008101345,0.0007202585,0.0002315434,0.9324489,0.0018495,0.00002874083,0.00354931],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.02328178,"threshold_uncertainty_score":0.08558089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4303204922681913,"score_gpt":0.5411292336209044,"score_spread":0.1108087413527131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}