{"id":"W3091971352","doi":"10.1128/jvi.01206-20","title":"Estradiol Enhances Antiviral CD4<sup>+</sup>Tissue-Resident Memory T Cell Responses following Mucosal Herpes Simplex Virus 2 Vaccination through an IL-17-Mediated Pathway","year":2020,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; McMaster University Medical Centre","funders":"Canadian Institutes of Health Research; Ontario HIV Treatment Network; Government of Canada","keywords":"Biology; Herpes simplex virus; Vaccination; Immunology; Immunity; Immune system; Immunization; Virus; Hormone; T cell; Virology; Nasal administration; Respiratory tract; Memory T cell; Vagina; Respiratory system; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001054367,0.0001618943,0.0001828888,0.0001134248,0.00005861104,0.0001700646,0.00006644776,0.0001225106,0.001592819],"category_scores_gemma":[0.0001412441,0.00006217867,0.0001142184,0.00005331325,0.0001393185,0.00009659395,0.0001089607,0.0002751248,0.0003382059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005731425,"about_ca_system_score_gemma":0.0001026075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001081255,"about_ca_topic_score_gemma":0.0002869265,"domain_scores_codex":[0.999909,0.00003097302,0.000005320987,0.000007942187,0.00001357052,0.00003311815],"domain_scores_gemma":[0.9999235,0.00002166329,0.00001600926,0.000007703936,0.000007935851,0.0000231508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001501245,0.0001897808,0.001068488,0.0000661488,0.000006421223,0.0001146199,0.00004346132,0.00007232382,0.9894305,0.00005324363,0.00009151337,0.007362295],"study_design_scores_gemma":[0.0001218115,0.006657317,0.0334408,0.00002186492,0.00004494287,0.0004167529,0.000177419,0.0004773709,0.9521325,0.0001261138,0.006375471,0.000007663745],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976221,0.0008685275,0.0002443988,0.00004762014,0.00003256259,0.000008282561,0.00004811805,0.00001660855,0.00111175],"genre_scores_gemma":[0.9963553,0.0005918962,0.0003616216,0.00005208962,0.00003079895,0.00001188203,0.00006661824,0.000009160712,0.002520717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001592819,"threshold_uncertainty_score":0.005328476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0231550127364798,"score_gpt":0.3046128420044508,"score_spread":0.281457829267971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}