{"id":"W3092008716","doi":"10.1038/s41467-020-18821-x","title":"Genome-wide chromatin accessibility is restricted by ANP32E","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; National Institute of General Medical Sciences; Medical Center, University of Rochester; U.S. Department of Health and Human Services; National Institutes of Health; Huntsman Cancer Institute; University of Rochester","keywords":"Chromatin; ChIA-PET; Nucleosome; Biology; Genome; Genetics; Epigenetics; ChIP-sequencing; Histone; Scaffold/matrix attachment region; Gene; Cell biology; Promoter; Computational biology; Epigenomics; Chromatin remodeling; Gene expression; DNA methylation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007560438,0.0001407664,0.0001290809,0.00001702492,0.0001946862,0.00004706371,0.001404986,0.0003392368,0.00003091744],"category_scores_gemma":[0.0002652995,0.0001448744,0.00008058034,0.0002153335,0.00009474834,0.000004821257,0.0006698014,0.0004458635,0.00002090983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000224771,"about_ca_system_score_gemma":0.00008109371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006592495,"about_ca_topic_score_gemma":0.00003670528,"domain_scores_codex":[0.9991007,0.00008796231,0.0002439021,0.0003006166,0.0001012839,0.0001655031],"domain_scores_gemma":[0.9979687,0.00003530087,0.0001231876,0.001631574,0.0001192389,0.0001220136],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002008503,0.0001327702,0.01564827,0.00002050138,0.0000730791,3.88569e-7,0.0002108419,0.00001067106,0.927672,0.0001693845,0.05559499,0.0004470743],"study_design_scores_gemma":[0.000904816,0.0002206369,0.1919992,0.00001083469,0.00005931504,0.000004942076,0.0001909883,0.005286216,0.04875156,0.0002423821,0.7516879,0.0006412377],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9733832,0.008521255,0.0006902703,0.01307562,0.00004613979,0.0002723339,0.0003192858,0.0000453243,0.003646506],"genre_scores_gemma":[0.9863011,0.001263083,0.005679179,0.004748856,0.00005783818,0.00002260987,0.001742098,0.00002333876,0.0001618994],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8789204,"threshold_uncertainty_score":0.5907805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01277650064771601,"score_gpt":0.273682574191041,"score_spread":0.260906073543325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}