{"id":"W3092008716","doi":"10.1038/s41467-020-18821-x","title":"Genome-wide chromatin accessibility is restricted by ANP32E","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; National Institute of General Medical Sciences; Medical Center, University of Rochester; U.S. Department of Health and Human Services; National Institutes of Health; Huntsman Cancer Institute; University of Rochester","keywords":"Chromatin; ChIA-PET; Nucleosome; Biology; Genome; Genetics; Epigenetics; ChIP-sequencing; Histone; Scaffold/matrix attachment region; Gene; Cell biology; Promoter; Computational biology; Epigenomics; Chromatin remodeling; Gene expression; DNA methylation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001929023,0.0002640616,0.0001961995,0.0001706307,0.0002127942,0.0004082147,0.0001610983,0.0001770704,0.0008762989],"category_scores_gemma":[0.0001805451,0.0002291656,0.0001753562,0.0001070102,0.0003174355,0.0001820252,0.0003839533,0.0003143295,0.0002233661],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002414871,"about_ca_system_score_gemma":0.0002041755,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008388082,"about_ca_topic_score_gemma":0.001812857,"domain_scores_codex":[0.999849,0.00002225443,0.00001025514,0.0000544614,0.0000413279,0.00002273721],"domain_scores_gemma":[0.9998257,0.00003791372,0.00004068017,0.0000324667,0.00001588809,0.00004745564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003133753,0.000002393368,0.0002568444,0.000005719066,0.000002245061,0.00001770393,0.000003852257,0.00002313249,0.9992269,0.00004616931,0.000006185172,0.0003774937],"study_design_scores_gemma":[0.00001521194,0.00009333636,0.01827967,0.000003528378,0.00001044133,0.000235354,0.0000269911,0.0008301025,0.9785432,0.0001660884,0.001789302,0.00000682216],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908531,0.00110733,0.005856228,0.00009604628,0.00001899789,0.00001398099,0.0001861954,0.00008249221,0.001785617],"genre_scores_gemma":[0.9968306,0.0004342678,0.001422258,0.00002880358,0.000004116993,0.00001612368,0.0001506414,0.00002035337,0.00109282],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008762989,"threshold_uncertainty_score":0.002931535,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01277650064771601,"score_gpt":0.273682574191041,"score_spread":0.260906073543325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}